A plant epigenetics researcher recounted a story in 2013 about the time she had given a talk at the Gordon Research Conference on Epigenetics, during which she mentioned the role of a transcription factor. After the talk, she was taken aside by one of the more seasoned researchers attending the meeting, who explained to her that “This is an epigenetics meeting. We don’t talk about transcription factors.” This anecdote illustrates how we traditionally dissociated the study of epigenetics from that of transcription factor biology. The silence about TFs in the epigenetics literature is our nonbarking dog. This omission is deliberate, not accidental.
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