The cDNA library that they were testing had a clone in a multiwell plate at column H and row 19, leading it to be referred to within the laboratory as the H19 gene (Tilghman 2014). Her group showed that H19 was noncod- ing and a neighbor of the imprinted Igf2 (Insulin-like growth factor 2) gene, and also imprinted, but expressed from the maternal chromosome, whereas Igf2 was expressed from the paternal chromosome. Through mutations of the nonexpressed sequences around H19, they also showed that the same enhancers worked on H19 and Igf2 and that there was a region critical for imprinting of both genes just on the Igf2 side of H19.
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