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Maybe scientific progress isn’t slowing, after all
September 27, 2026Can you hack your gut microbiome?
September 27, 2026https://www.economist.com/science-and-technology/2026/08/07/can-you-hack-your-gut-microbiome
can you hack your gut microbiome
is the histamine in the stomach and that in asthma the same – Google Search
September 27, 2026https://www.google.com/search?q=is+the+histamine+in+the+stomach+and+that+in+asthma+the+same&sca_esv=518d4d1493045c4f&biw=1961&bih=1427&sxsrf=APpeQnuAbG6ZxEOzHZ8V2lJff7jZJoI8rw%3A1788754567743&ei=hzqeauf9LMSYptQP1ofxiQU&ved=2ahUKEwin3eaEztuWAxVEjIkEHdZDPFEQ4dUDegQIBhAM&uact=5&oq=is+the+histamine+in+the+stomach+and+that+in+asthma+the+same&gs_lp=Egxnd3Mtd2l6LXNlcnAiO2lzIHRoZSBoaXN0YW1pbmUgaW4gdGhlIHN0b21hY2ggYW5kIHRoYXQgaW4gYXN0aG1hIHRoZSBzYW1lMgUQIRigATIFECEYoAEyBRAhGKABMgUQIRirAjIFECEYqwJIs31QyCJYqXtwAngBkAEAmAF5oAGGKaoBBTQ1LjE0uAEDyAEA-AEBmAI9oAKAK8ICChAAGEcY1gQYsAPCAg4QABjkAhjWBBiwA9gBAcICFxAuGNwGGLgGGNoGGNgCGMgDGLAD2AEBwgIaEC4Y3AYYuAYY2gYY2AIY5QQYyAMYsAPYAQHCAgQQIxgnwgILEAAYgAQYigUYkQLCAgsQABiABBixAxiDAcICCBAAGIAEGLEDwgINECMY8AUYngYYogcYJ8ICChAAGIAEGIoFGEPCAg0QIxiiBxieBhjwBRgnwgIKEAAYgAQYFBiHAsICDhAAGIAEGIoFGLEDGIMBwgIFEAAYgATCAgYQABgWGB7CAggQABgWGB4YCsICCxAAGIAEGIoFGIYDwgIIEAAYgAQYogTCAgUQABjvBcICBRAhGJ8FmAMAiAYBkAYPugYGCAEQARgJkgcFNDIuMTmgB6vnA7IHBTQwLjE5uAfxKsIHBzAuMzcuMjTIB6YBgAgB&sclient=gws-wiz-serp QT:{{” Yes, the actual histamine molecule found in the stomach and the one involved in asthma are chemically identical. [1, 2]
However, they act on different receptor subtypes and serve different biological functions. [1, 2]
How Histamine Works in the Body
The Molecule: Histamine is a single organic nitrogen compound (biogenic amine) produced naturally by the body and found in certain foods. [1, 2, 3]
The Receptors: The effects of histamine depend entirely on which type of histamine receptor it binds to in different tissues. There are four main receptor types (H1, H2, H3, and H4). [1, 2, 3]
Stomach Histamine vs. Asthma Histamine
In the Stomach: Histamine primarily binds to H2 receptors located on parietal cells. This binding stimulates the secretion of gastric acid to help digest food. This is why medications like famotidine are called H2 blockers—they target stomach receptors to reduce acid. [1, 2, 3, 4, 5]
In Asthma: Histamine released during an allergic reaction binds primarily to H1 receptors in the airways. This binding causes smooth muscle contraction (bronchospasm), swelling (edema), and excess mucus production, which constricts the lungs. Traditional allergy
medications are H1 antihistamines designed to block these airway and systemic allergy symptoms. [1, 2, 3, 4, 5]
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NYTimes: After OpenAI’s Bots Went Rogue, Watchdogs Were Kept on a Short Leash
September 27, 2026thought ‘bot interaction/collaboration was highlighted
https://www.nytimes.com/2026/09/03/technology/openai-hugging-face-hack.html?smid=nytcore-ios-share
Amazon.com : induction cooktop
September 27, 2026]
https://www.amazon.com/s?k=induction+cooktop&channelId=500&clpRedir=Y&plpRedirect=mhFallback new type of gas free cooking
Yale DSS courselist
September 27, 2026Stat courses in 2026-2027
http://www.stat.yale.edu/Courses/2026-27
NYTimes: The 92-Year-Old Mathematician and the Teenage Apprentice
September 27, 2026migration of keratinocytes from the stratum basale – Google Search
September 27, 2026https://www.google.com/search?q=migration+of+keratinocytes+from+the+stratum+basale&oq=migration+of+ker&gs_lcrp=EgZjaHJvbWUqBwgBEAAYgAQyBggAEEUYOTIHCAEQABiABDIHCAIQABiABDIICAMQABgWGB4yCAgEEAAYFhgeMggIBRAAGBYYHjIICAYQABgWGB4yCAgHEAAYFhgeMggICBAAGBYYHjIICAkQABgWGB7SAQg4NjQ5ajBqNKgCALACAA&sourceid=chrome&source=chrome.ob&ie=UTF-8 QT:{{” Keratinocytes migrate upward from the Stratum Basale to the outer skin surface in about 2 to 4 weeks. [1, 2]
The Migration Process
Origin: Cells start in the deepest layer of the epidermis, called the stratum basale, where stem cells divide to create new keratinocytes. [1, 2]
Journey: As new cells form, they push older cells upward through the intermediate layers: the stratum spinosum and the stratum granulosum. [1, 2]
Change (Differentiation): During this upward movement, cells change shape, flatten, produce keratin protein, and lose their nuclei to become dead, protective cells called corneocytes. [1, 2, 3]
Shedding (Desquamation): The flattened cells reach the outermost layer—the stratum corneum—stay there for roughly two weeks, and then shed off the body. [1, 2]
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keratinocytes form ideal shapes discovered in 2016 – Google Search
September 27, 2026QT:{{” In 2016, a team of scientists led by researchers from Kyoto University and Keio University discovered that granular keratinocytes in mammalian skin adopt a flattened Kelvin’s tetrakaidecahedron (f-TKD). [1, 2]
This 14-sided solid polyhedron—consisting of six rectangular and eight hexagonal sides—was first proposed by the British physicist Lord Kelvin in 1887 as the mathematically ideal shape for filling space with the least amount of surface area, much like how bubbles fit together in a foam. [1, 2]
Why This Shape Matters
The discovery, published in Scientific Reports / EMBO Journal by Yokouchi et al. (2016), solved a long-standing mystery in biology: how the skin maintains a continuous, leak-proof barrier while constantly shedding cells. [1, 2]
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