Mattick & Dinger
The extent of functionality in the human genome
http://www.thehugojournal.com/content/7/1/2/
Archive for the 'SciLit' Category
FYI: Another Encode Commentary Paper
August 4, 2013PLOS Collections: A Primer on Regression Methods for Decoding cis-Regulatory Logic
August 4, 2013#Regression Methods for Decoding cis-Regulatory Logic, incl. interaction terms & non-linear sigmoidal relationships
http://www.ploscollections.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000269
Global Epigenomic Reconfiguration During Mammalian Brain Development
July 27, 2013Lister… Ecker
MT @BiomedRevon: Global #epigenomic reconfiguration during mammalian #brain development http://bit.ly/16lbboa cortex methylation over time
A “map showing how methylation changes in the frontal cortex over time. During the first two years of life… a wave of methylation alters the DNA in genes ”
http://www.sciencemag.org/content/early/2013/07/05/science.1237905
An Information-Theoretic Machine Learning Approach to Expression QTL Analysis
July 26, 2013An Information-Theoretic Machine Learning Approach to Expression QTL Analysis Tao Huang, Yu-Dong Cai
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0067899
The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology
July 20, 2013The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology
Cancer Res July 15, 2013 73:4372-4382; Published OnlineFirst July 15, 2013; http://cancerres.aacrjournals.org/content/73/14/4372.long
The Mycobacterium tuberculosis regulatory network and hypoxia
July 13, 2013http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12337.html#
QT:”
We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. …Using ChIP-Seq combined with expression
data from the induction of the same factors, we have reconstructed a draft regulatory network based on 50 transcription factors….The regulatory network reveals transcription factors
underlying these changes, allows us to computationally predict expression changes, and indicates that Rv0081 is a regulatory hub. “
Dead or Alive?
July 7, 2013Dead or Alive? Pseudoenzymes resemble #enzymes but difficult to pin down functionally http://www.sciencemag.org/content/340/6128/27.full #pseudogene
http://www.sciencemag.org/content/340/6128/27.full
Science 5 April 2013:
Vol. 340 no. 6128 p. 27
DOI: 10.1126/science.340.6128.27
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Dead or Alive?
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