An interesting paper with implications for personalized nutrition, suggested to me by
@DrGarrettAsh1
https://link.springer.com/article/10.1007%2Fs13300-021-01174-z Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults
…
Represents an update to “Personalized Nutrition by Prediction of Glycemic Responses” from the
@segal_eran
lab (https://cell.com/fulltext/S0092-8674(15)01481-6)
cell.com
Personalized Nutrition by Prediction of Glycemic Responses
…
Also, I felt this easy to read
@NewScientist
overview was quite relevant to these works & put them into a larger
context https://newscientist.com/article/mg24732990-600-why-there-is-no-such-thing-as-a-healthy-diet-that-works-for-everyone/ Why there is no such thing as a healthy diet that works for everyone
Archive for the 'SciLit' Category
Why there is no such thing as a healthy diet that works for everyone | New Scientist
December 18, 2021Mapping the human genetic architecture of COVID-19 | Nature
December 16, 2021Origins and evolution of extreme life span in Pacific Ocean rockfishes
November 23, 2021Sublimation-driven morphogenesis of Zen stones on ice surfaces | PNAS
November 23, 2021https://www.pnas.org/content/118/40/e2109107118
Nicolas Taberlet & Nicolas Plihon
PNAS October 5, 2021 118 (40) e2109107118;
https://doi.org/10.1073/pnas.2109107118
A single-cell atlas of chromatin accessibility in the human genome: Cell
November 12, 2021https://www.cell.com/cell/fulltext/S0092-8674(21)01279-4
A single-cell atlas of chromatin accessibility in the human genome
Kai Zhang 8
James D. Hocker 8
Michael Miller
….
Allen Wang
Sebastian Preissl
Bing Ren 9
Published:November 12, 2021
DOI:https://doi.org/10.1016/j.cell.2021.10.024
A wider field of view to predict expression | Nature Methods
November 10, 2021A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.
Yang Young Lu and William Staford Noble
The triumphs and limitations of computational methods for scRNA-seq | Nature Methods
November 10, 2021Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.
Note also the reference to expression entropy for determining the direction in trajectories.
Review Article
Published: 21 June 2021
The triumphs and limitations of computational methods for scRNA-seq
Peter V. Kharchenko
Nature Methods volume 18, pages723–732 (2021)
Anatomical structures, cell types and biomarkers of the Human Reference Atlas
November 10, 2021Anatomical structures, cell types and biomarkers of the Human Reference Atlas https://www.nature.com/articles/s41556-021-00788-6.pdf
cell type specific brain eQTL paper preprint
November 3, 2021UK Biobank 450k Whole Exome release coming soon on the Research Analysis Platform
November 2, 2021Article
Published: 18 October 2021
Exome sequencing and analysis of 454,787 UK Biobank participants
Joshua D. Backman, Alexander H. Li, Anthony Marcketta, Dylan Sun, Joelle Mbatchou, Michael D. Kessler, Christian Benner, Daren Liu, Adam E. Locke, Suganthi Balasubramanian, Ashish Yadav, Nilanjana Banerjee, Christopher Gillies, Amy Damask, Simon Liu, Xiaodong Bai, Alicia Hawes, Evan Maxwell, Lauren Gurski, Kyoko Watanabe, Jack A. Kosmicki, Veera Rajagopal, Jason Mighty, Regeneron Genetics Center, DiscovEHR, Marcus Jones, Lyndon Mitnaul, Eli Stahl, Giovanni Coppola, Eric Jorgenson, Lukas Habegger, William J. Salerno, Alan R. Shuldiner, Luca A. Lotta, John D. Overton, Michael N. Cantor, Jeffrey G. Reid, George Yancopoulos, Hyun M. Kang, Jonathan Marchini, Aris Baras, Gonçalo R. Abecasis & Manuel A. Ferreira -Show fewer authors
Nature (2021)
https://www.nature.com/articles/s41586-021-04103-z
seems to be an incredible data set – 450K exomes!
linkstream2 microblog 