Archive for the 'SciLit' Category

De novo protein design by deep network hallucination

January 5, 2022

https://www.nature.com/articles/s41586-021-04184-w

Anishchenko, Ivan, et al. “De novo protein design by deep network hallucination.” Nature (2021): 1-6.

Understanding adversarial examples requires a theory of artefacts for deep learning | Nature Machine Intelligence

January 2, 2022

https://www.nature.com/articles/s42256-020-00266-y

Why there is no such thing as a healthy diet that works for everyone | New Scientist

December 18, 2021

An interesting paper with implications for personalized nutrition, suggested to me by
@DrGarrettAsh1
https://link.springer.com/article/10.1007%2Fs13300-021-01174-z Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults
…
Represents an update to “Personalized Nutrition by Prediction of Glycemic Responses” from the
@segal_eran
lab (https://cell.com/fulltext/S0092-8674(15)01481-6)
cell.com
Personalized Nutrition by Prediction of Glycemic Responses
…
Also, I felt this easy to read
@NewScientist
overview was quite relevant to these works & put them into a larger
context https://newscientist.com/article/mg24732990-600-why-there-is-no-such-thing-as-a-healthy-diet-that-works-for-everyone/ Why there is no such thing as a healthy diet that works for everyone

Mapping the human genetic architecture of COVID-19 | Nature

December 16, 2021

https://www.nature.com/articles/s41586-021-03767-x

Origins and evolution of extreme life span in Pacific Ocean rockfishes

November 23, 2021

https://www.science.org/doi/10.1126/science.abg5332

Sublimation-driven morphogenesis of Zen stones on ice surfaces | PNAS

November 23, 2021

https://www.pnas.org/content/118/40/e2109107118

Nicolas Taberlet & Nicolas Plihon
PNAS October 5, 2021 118 (40) e2109107118;
https://doi.org/10.1073/pnas.2109107118

A single-cell atlas of chromatin accessibility in the human genome: Cell

November 12, 2021

https://www.cell.com/cell/fulltext/S0092-8674(21)01279-4

A single-cell atlas of chromatin accessibility in the human genome

Kai Zhang 8
James D. Hocker 8
Michael Miller
….
Allen Wang
Sebastian Preissl
Bing Ren 9

Published:November 12, 2021
DOI:https://doi.org/10.1016/j.cell.2021.10.024

A wider field of view to predict expression | Nature Methods

November 10, 2021

A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.

Yang Young Lu and William Staford Noble

https://www.nature.com/articles/s41592-021-01259-4

The triumphs and limitations of computational methods for scRNA-seq | Nature Methods

November 10, 2021

Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.

Note also the reference to expression entropy for determining the direction in trajectories.

Review Article
Published: 21 June 2021

The triumphs and limitations of computational methods for scRNA-seq

Peter V. Kharchenko

Nature Methods volume 18, pages723–732 (2021)

https://www.nature.com/articles/s41592-021-01171-x

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

November 10, 2021

Anatomical structures, cell types and biomarkers of the Human Reference Atlas https://www.nature.com/articles/s41556-021-00788-6.pdf