https://www.nature.com/articles/s41586-021-04184-w
Anishchenko, Ivan, et al. “De novo protein design by deep network hallucination.” Nature (2021): 1-6.
https://www.nature.com/articles/s41586-021-04184-w
Anishchenko, Ivan, et al. “De novo protein design by deep network hallucination.” Nature (2021): 1-6.
An interesting paper with implications for personalized nutrition, suggested to me by
@DrGarrettAsh1
https://link.springer.com/article/10.1007%2Fs13300-021-01174-z Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults
…
Represents an update to “Personalized Nutrition by Prediction of Glycemic Responses” from the
@segal_eran
lab (https://cell.com/fulltext/S0092-8674(15)01481-6)
cell.com
Personalized Nutrition by Prediction of Glycemic Responses
…
Also, I felt this easy to read
@NewScientist
overview was quite relevant to these works & put them into a larger
context https://newscientist.com/article/mg24732990-600-why-there-is-no-such-thing-as-a-healthy-diet-that-works-for-everyone/ Why there is no such thing as a healthy diet that works for everyone
https://www.pnas.org/content/118/40/e2109107118
Nicolas Taberlet & Nicolas Plihon
PNAS October 5, 2021 118 (40) e2109107118;
https://doi.org/10.1073/pnas.2109107118
https://www.cell.com/cell/fulltext/S0092-8674(21)01279-4
A single-cell atlas of chromatin accessibility in the human genome
Kai Zhang 8
James D. Hocker 8
Michael Miller
….
Allen Wang
Sebastian Preissl
Bing Ren 9
Published:November 12, 2021
DOI:https://doi.org/10.1016/j.cell.2021.10.024
A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.
Yang Young Lu and William Staford Noble
Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.
Note also the reference to expression entropy for determining the direction in trajectories.
Review Article
Published: 21 June 2021
The triumphs and limitations of computational methods for scRNA-seq
Peter V. Kharchenko
Nature Methods volume 18, pages723–732 (2021)
Anatomical structures, cell types and biomarkers of the Human Reference Atlas https://www.nature.com/articles/s41556-021-00788-6.pdf