https://genome.cshlp.org/content/early/2021/04/08/gr.260851.120.abstract
Archive for the 'SciLit' Category
Interpretation of allele-specific chromatin accessibility using cell state-aware deep learning
May 18, 2021Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression | Bioinformatics | Oxford Academic
May 3, 2021Nice analysis integrating bulk & single-cell data, to get at inter-individual differences in the expression of genes in specific
cell types https://academic.OUP.com/bioinformaticsformatics/article/36/3/782/5545976
Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression
https://academic.oup.com/bioinformatics/article/36/3/782/5545976
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose | Science
May 2, 2021Pre-symptomatic detection of COVID-19 from smartwatch data | Nature Biomedical Engineering
April 28, 2021Human local adaptation of the TRPM8 cold receptor along a latitudinal cline
April 7, 2021Stumbled onto this paper. Thought the conclusion that Europeans were more cold-sensitive due to TRPM8 was quite counter-intuitive – but interesting nevertheless
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007298
cold receptor
Low rattling: A predictive principle for self-organization in active collectives | Science
January 29, 2021pseudogenes/odorant receptors
December 17, 2020Sequence Variants in TAAR5 & Other Loci Affect Human Odor Perception & Naming https://www.cell.com/current-biology/fulltext/S0960-9822(20)31343-9 A variant in TAAR5 affects the perception of fish odor. Interesting to consider in relation to pseudogenization of the olfactory receptors
While about half of human odorant receptors are thought to be pseudogenes with loss-of-function, the Decode Genetics folks show that some sequence variants in odorant receptor genes are not
loss-of-function.
A human cell atlas of fetal gene expression | Science
November 14, 2020https://science.sciencemag.org/content/370/6518/eaba7721
+
https://science.sciencemag.org/content/370/6518/eaba7612
15 tissues (incl. brain), fetal, RNA+atac
BY JUNYUE CAO, DIANA R. O’DAY, HANNAH A. PLINER, PAUL D. KINGSLEY, MEI DENG, RIZA M. DAZA, MICHAEL A. ZAGER, KIMBERLY A. ALDINGER, RONNIE BLECHER-GONEN, FAN ZHANG, MALTE SPIELMANN, JAMES PALIS, DAN DOHERTY, FRANK J. STEEMERS, IAN A. GLASS, COLE TRAPNELL, JAY SHENDURE SCIENCE13 NOV 2020
linkstream2 microblog 