Archive for the 'SciLit' Category

Complement Factor H Polymorphism in Age-Related Macular Degeneration | Science

October 12, 2019

https://science.sciencemag.org/content/308/5720/385.long

Robert J. Klein1, Caroline Zeiss2,*, Emily Y. Chew3,*, Jen-Yue Tsai4,*, Richard S. Sackler1, Chad Haynes1, Alice K. Henning5, John Paul SanGiovanni3, Shrikant M. Mane6, Susan T. Mayne7, Michael B. Bracken7, Frederick L. Ferris3, Jurg Ott1, Colin Barnstable2, Josephine Hoh7,†

see https://plu.mx/mtsinai/u/rklein

Complement Factor H Polymorphism in Age-Related Macular Degeneration

October 12, 2019

https://en.wikipedia.org/wiki/Factor_H

Complement Factor H Polymorphism in Age-Related Macular Degeneration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512523/

gene name Cfh

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference: The American Journal of Human Genetics

October 8, 2019

https://www.cell.com/ajhg/fulltext/S0002-9297(13)00289-9#%20

Diabetes and RACE A Historical Perspective

October 5, 2019

ethnicity & diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000712/

Biological composites—complex structures for functional diversity | Science

September 30, 2019

http://science.sciencemag.org/content/362/6414/543

QT:{{”
An example is the combination of rigidity and flexibility in protein-based teeth of the squid sucker ring. Other examples are time-delayed actuation in plant seed pods triggered by environmental signals, such as fire and water, and surface nanostructures that combine light manipulation with mechanical protection or water repellency. Bioinspired engineering transfers some of these structural principles into technically more relevant base materials to obtain new, often unexpected combinations of material properties. Less appreciated is the huge potential of using bioinspired structural complexity to avoid unnecessary chemical diversity, enabling easier recycling and, thus, a more sustainable materials economy.
“}}

DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing

September 30, 2019

DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392537/

Modern humans may be evolving to deal with carbohydrate-rich diets – Diet and evolution

September 29, 2019

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism | eLife
https://elifesciences.org/articles/41517

Matteo Fumagalli, Stephane M Camus, Yoan Diekmann, Alice Burke, Marine D Camus, Paul J Norman, Agnel Joseph, Laurent Abi-Rached, Andrea Benazzo, Rita Rasteiro, Iain Mathieson, Maya Topf, Peter Parham, Mark G Thomas, Frances M Brodsky

evolutionary history CLTCL1 from 1000 genomes

https://www.economist.com/science-and-technology/2019/06/08/modern-humans-may-be-evolving-to-deal-with-carbohydrate-rich-diets

Modelling the recent common ancestry of all living humans | Nature

September 29, 2019

https://www.nature.com/articles/nature02842

Published: 30 September 2004

Modelling the recent common ancestry of all living humans
Douglas L. T. Rohde, Steve Olson & Joseph T. Chang

Avoiding the pitfalls of single particle cryo-electron microscopy: Einstein from noise | PNAS

September 28, 2019

Avoiding the pitfalls of single-particle #cryoEM: Einstein from noise https://www.PNAS.org/content/110/45/18037 A great paper, explaining in simple terms how you can fool yourself with fancy computer algorithms. However, perhaps it’s a bit too honest – only a Nobelist could write this!

Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects | Nature Communications

September 10, 2019

https://www.nature.com/articles/s41467-018-06159-4