http://www.nature.com/news/brainstorming-is-not-the-way-to-discuss-scientific-issues-1.21951
Archive for the 'SciLit' Category
With all due respect to Maholo, lab automation isn’t anthropomorphic : Nature Biotechnology : Nature Research
May 15, 2017Guidelines for DNA Hybrid Molecules | Science
May 15, 2017Singer & Soll
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors : Nature Genetics : Nature Research
May 6, 2017http://www.nature.com/ng/journal/v49/n5/full/ng.3818.html
Ref component analysis..of transcriptomes, by @Robson_Paul &co http://www.Nature.com/ng/journal/v49/n5/full/ng.3818.html Clustering similarity of samples to tissue references
Evolution of Bow-Tie Architectures in Biology
April 28, 2017Evolution of BowTie Architectures http://journals.PLOS.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004055 3-layer, in-mid-out systems can have small a waist when their goal is compressible
Aging increases cell-to-cell transcriptional variability upon immune stimulation | Science
April 21, 2017#Aging increases cell-to-cell transcriptional variability upon immune stimulation, but just for 225 up-reg. genes http://science.ScienceMag.org/content/355/6332/1433
Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression: Cell
April 16, 2017"Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression"
(http://www.sciencedirect.com/science/article/pii/S0092867417301289)
#Neanderthal-Introgressed Sequences [&]…Gene Expression http://www.Cell.com/cell/abstract/S0092-8674(17)30128-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867417301289%3Fshowall%3Dtrue ASE for Hn SNPs shows lower #brain expression vs reference
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. – PubMed – NCBI
April 16, 2017#IHEC: A Blueprint for…Collab. & Discovery
http://www.Cell.com/cell/abstract/S0092-8674(16)31528-8?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416315288%3Fshowall%3Dtrue Summary bullets on heterogeneity, disease, rel. to SNPs, comp. tools
NAR Breakthrough Article: denovo-db: a compendium of human de novo variants
April 3, 2017.@denovodb: a compendium of [initially ~33K] human de novo variants w. phenotype, freely downloadable as a TSV table
https://academic.OUP.com/nar/article-lookup/doi/10.1093/nar/gkw865
QT:{{”
As of July 2016, denovo-db contained 40 different studies and 32,991 de novo variants from 23,098 trios. Database features include basic variant information (chromosome location, change, type); detailed annotation at the transcript and protein levels; severity scores; frequency; validation status; and, most importantly, the phenotype of the individual with the variant.
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denovo-db.gs.washington.edu/denovo-db/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210614/
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