Archive for the 'SciLit' Category

Learning single-cell perturbation responses using neural optimal transport | Nature Methods

January 18, 2025

https://www.nature.com/articles/s41592-023-01969-x

Bunne, C., Stark, S. G., Gut, G., Del Castillo, J. S., Levesque, M., Lehmann, K., Pelkmans, L., Krause, A., & Rätsch, G. (2023). Learning single-cell perturbation responses using neural optimal transport. Nature Methods, 20(11), 1759–1768.
https://doi.org/10.1038/s41592-023-01969-x

not so useful for learning OT

Accurate proteome-wide missense variant effect prediction with AlphaMissense | Science

December 31, 2024

https://www.science.org/doi/10.1126/science.adg7492

Cheng, J., Novati, G., Pan, J., Bycroft, C., Žemgulytė, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., W, A., Senior, Jumper, J., Hassabis, D., Kohli, P., & Avsec, Ž. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense. Science, 381(6664).
https://doi.org/10.1126/science.adg7492

Limits to economic growth | Nature Physics

December 24, 2024

https://www.nature.com/articles/s41567-022-01652-6

Murphy, T. W. (2022). Limits to economic growth. Nature Physics, 18(8), 844–847. https://doi.org/10.1038/s41567-022-01652-6

The persistence of smoke VOCs indoors: Partitioning, surface cleaning, and air cleaning in a smoke-contaminated house | Science Advances

December 22, 2024

https://www.science.org/doi/10.1126/sciadv.adh8263

QT:{{”
Many volatile organic compounds (VOCs) persisted days following the smoke injection, providing a longer-term exposure pathway for humans….These rates imply that vapor pressure controls partitioning behavior and that house ventilation plays a minor role in removing smoke VOCs. However, surface cleaning activities (vacuuming, mopping, and dusting) physically removed surface reservoirs and thus reduced indoor smoke VOC concentrations more effectively than portable air cleaners and more persistently than window opening.
“}}

What is scaling? – ScienceDirect

December 8, 2024

https://www.sciencedirect.com/science/article/pii/S0883902623000691

Benchmarking joint multi-omics dimensionality reduction approaches for the study of cancer | Nature Communications

November 20, 2024

https://www.nature.com/articles/s41467-020-20430-7

Crystal Structure Determination from Powder Diffraction Patterns with Generative Machine Learning | Journal of the American Chemical Society

November 14, 2024

https://pubs.acs.org/doi/10.1021/jacs.4c10244

Riesel, E. A., Mackey, T., Nilforoshan, H., Xu, M., Badding, C. K., Altman, A. B., Leskovec, J., & Freedman, D. E. (2024). Crystal Structure Determination from Powder Diffraction Patterns with Generative Machine Learning. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.4c10244

seems to use a form of “steered diffusion” to match the powder pattern

The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of “retrobiome ” in naked mole rat | PNAS

November 10, 2024

https://www.pnas.org/doi/10.1073/pnas.2313581121

Kogan, V., Molodtsov, I., Fleyshman, D. I., Leontieva, O. V., Koman, I. E., & Gudkov, A. V. (2024). The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of “retrobiome” in naked mole rat. Proceedings of the National Academy of Sciences, 121(45). https://doi.org/10.1073/pnas.2313581121

Molecular quantitative trait loci | Nature Reviews Methods Primers

November 10, 2024

https://www.nature.com/articles/s43586-022-00188-6

Nature Reviews Methods Primers

Aguet, F., Alasoo, K., Li, Y. I., Battle, A., Im, H. K., Montgomery, S. B., & Lappalainen, T. (2023). Molecular quantitative trait loci. Nature Reviews Methods Primers, 3(1).
https://doi.org/10.1038/s43586-022-00188-6

Variation in human water turnover associated with environmental and lifestyle factors | Science

November 10, 2024

from podcast
QT:{{”

….Okay. So when you got measurements from this big group
of people, you end up
with kind of a range of water turnover and it varies by person and location. So how does this range
that you measured in this diverse group of people? How does it stack up with eight, eight ounce
glasses a day, which is like two liters of water a day, that recommendation we discussed?
Most people are not going to need to drink, eight
glasses of water a day, two liters of
water a day. If you measure how much water flows through your body, how much water comes in
and goes out every day, there’s a lot of variation, but it’s something like three to four liters a day
total. And that includes not just the water that you drink, but that includes the water that’s in the
food that you eat.
“}}

https://www.science.org/doi/10.1126/science.abm8668