Quantum computer at Barcelona Supercomputer Center (BSC)
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Posts Tagged ‘bb’
images of a QC in a chuch
July 30, 2026Genome-wide association studies | Nature Reviews Methods Primers
January 25, 2025g accounts for the cumulative effect of all other variants on the phenotype besides the effect of the specific variant being tested (SNP s).
Although theoretically we should consider the effect of g when testing for GWAS associations, in practice don’t think this happens in standard GWAS tools, such as PLINK and REGENIE (see below).
PLINK: https://www.cog-genomics.org/plink/2.0/assoc
REGENIE: https://www.nature.com/articles/s41588-021-00870-7#Sec10
https://www.nature.com/articles/s43586-021-00056-9
Bioart
November 7, 2024Quantitative GWAS & QTL studies
February 25, 2023Primer
Published: 25 January 2023
Molecular quantitative trait loci
François Aguet, Kaur Alasoo, Yang I. Li, Alexis Battle, Hae Kyung Im, Stephen B. Montgomery & Tuuli Lappalainen
Nature Reviews Methods Primers volume 3, Article number: 4 (2023)
Related to the discussion about quantitative GWAS and QTL, this primer review (and in particular box 1) is helpful in clarifying the (non) difference between the two types of studies:
https://www.nature.com/articles/s43586-022-00188-6
The statistics behind quantitative GWAS and QTL studies is the same, the only main difference might be the multiple testing correction procedure.
In general, it’s more a nomenclature distinction, as the term “QTL” is often used specifically for molecular traits.
linkstream2 microblog 
