Archive for the 'SciLit' Category

Evolution of a minimal cell | Nature

September 2, 2024

Moger-Reischer, R. Z., Glass, J. I., Wise, K. S., Sun, L.,
Bittencourt, D. M. C., Lehmkuhl, B. K., Schoolmaster, D. R., Lynch, M., & Lennon, J. T. (2023). Evolution of a minimal cell. Nature, 620(7972), 122–127. https://doi.org/10.1038/s41586-023-06288-x

https://www.nature.com/articles/s41586-023-06288-x

A 160 Gbp fork fern genome shatters size record for eukaryotes: iScience

August 31, 2024

https://www.cell.com/iscience/fulltext/S2589-0042(24)01111-8

https://www.cell.com/iscience/fulltext/S2589-0042(24)01111-8

https://doi.org/10.1016/j.isci.2024.109889

A Unification of Mediator, Confounder, and Collider Effects – PMC

August 31, 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967310/

MacKinnon, D. P., & Lamp, S. J. (2021). A unification of mediator, confounder, and collider effects. Prevention Science, 22(8), 1185–1193. https://doi.org/10.1007/s11121-021-01268-xMacKinnon, D. P., & Lamp, S. J. (2021). A unification of mediator, confounder, and collider effects. Prevention Science, 22(8), 1185–1193.
https://doi.org/10.1007/s11121-021-01268-x

QT:{{”
Third-variable effects are not distinguishable solely by statistical methods. Each third-variable effect can be fit to the same data, and if the relations between the variables are substantial, there will be evidence for each effect. In this sense, the confounder, mediator, and collider models are equivalent, providing an equal representation of the information contained in the data for three variables (Stelzl, 1986). Although mediation, confounding, and collision may equally explain the statistical associations among three variables, they describe different causal relations among those variables. Like much recent research on causal analysis, this paper highlights the centrality of the causal model underlying a research study and the important distinction between the causal model and the statistical model. The appropriate causal model is determined by prior empirical research and theory. The statistical analysis provides estimates for the proposed causal model.
“}}

A Unification of Mediator, Confounder, and Collider Effects – PMC

August 31, 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967310/

MacKinnon, D. P., & Lamp, S. J. (2021). A unification of mediator, confounder, and collider effects. Prevention Science, 22(8), 1185–1193. https://doi.org/10.1007/s11121-021-01268-xMacKinnon, D. P., & Lamp, S. J. (2021). A unification of mediator, confounder, and collider effects. Prevention Science, 22(8), 1185–1193.
https://doi.org/10.1007/s11121-021-01268-x

QT:{{”
Third-variable effects are not distinguishable solely by statistical methods. Each third-variable effect can be fit to the same data, and if the relations between the variables are substantial, there will be evidence for each effect. In this sense, the confounder, mediator, and collider models are equivalent, providing an equal representation of the information contained in the data for three variables (Stelzl, 1986). Although mediation, confounding, and collision may equally explain the statistical associations among three variables, they describe different causal relations among those variables. Like much recent research on causal analysis, this paper highlights the centrality of the causal model underlying a research study and the important distinction between the causal model and the statistical model. The appropriate causal model is determined by prior empirical research and theory. The statistical analysis provides estimates for the proposed causal model.
“}}

Review: Computational methods for allele-specific expression in single cells

August 17, 2024

https://www.sciencedirect.com/science/article/pii/S0168952524001690?via%3Dihub

2302.04265 PFGM++: Unlocking the Potential of Physics-Inspired Generative Models

August 11, 2024

https://arxiv.org/abs/2302.04265

thought this was interesting

Xu, Y., Liu, Z., Tian, Y., Tong, S., Tegmark, M., & Jaakkola, T. (2023, February 8). PFGM++: Unlocking the potential of
Physics-Inspired Generative Models. arXiv.org.
https://arxiv.org/abs/2302.04265

Detecting hallucinations in large language models using semantic entropy | Nature

August 11, 2024

https://www.nature.com/articles/s41586-024-07421-0

Farquhar, S., Kossen, J., Kuhn, L., & Gal, Y. (2024). Detecting hallucinations in large language models using semantic entropy. Nature, 630(8017), 625–630. https://doi.org/10.1038/s41586-024-07421-0

CATHe: detection of remote homologues for CATH superfamilies using embeddings from protein language models | Bioinformatics | Oxford Academic

July 28, 2024

Nallapareddy, V., Bordin, N., Sillitoe, I., Heinzinger, M., Littmann, M., Waman, V. P., Sen, N., Rost, B., & Orengo, C. (2023). CATHe: detection of remote homologues for CATH superfamilies using embeddings from protein language models. Bioinformatics, 39(1).
https://doi.org/10.1093/bioinformatics/btad029

https://academic.oup.com/bioinformatics/article/39/1/btad029/6989624

Single-cell multiregion dissection of Alzheimer’s disease | Nature

July 24, 2024

https://www.nature.com/articles/s41586-024-07606-7

Induction of social contagion for diverse outcomes in structured experiments in isolated villages | Science

May 3, 2024

https://www.science.org/doi/10.1126/science.adi5147

Honduras !