Archive for the 'x78qt' Category

Huge brain study uncovers ‘buried’ genetic networks linked to mental illness

December 15, 2018

https://www.nature.com/articles/d41586-018-07750-x

Huge Brain Study Uncovers “Buried” Genetic Networks Linked to Mental Illness – Scientific American

December 15, 2018

https://www.scientificamerican.com/article/huge-brain-study-uncovers-buried-genetic-networks-linked-to-mental-illness/

Genetic analysis reveals brain changes that lead to mental illness – UPI.com

December 15, 2018

https://www.upi.com/Health_News/2018/12/14/Genetic-analysis-reveals-brain-changes-that-lead-to-mental-illness/3051544806383/

In the developing brain, scientists find roots of neuropsychiatric diseases | YaleNews

December 15, 2018

https://news.yale.edu/2018/12/13/developing-brain-scientists-find-roots-neuropsychiatric-diseases

yale press release

PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features | GenomeWeb

December 15, 2018

https://www.genomeweb.com/sequencing/psychencode-studies-explore-brain-development-neuropsychiatric-regulatory-features#.XBRjaxNKgWo

University Science Strategy Committee Report

June 20, 2018

Long-awaited @Yale STEM report calls for new research institutes
https://YaleDailyNews.com/blog/2018/06/14/long-awaited-stem-report-calls-for-new-research-institutes Top recommendation is a new #DataScience institute! Followed by one for #Neuroscience. Cross-cutting recommendations on grad. student support & sci. cores (https://research.Yale.edu/ussc-report)

Blog post itself has some interesting “text evolution”:
http://meetings.gersteinlab.org/2018/06.20/Text-evolution-of-USSC-news-article

Points from the new University Science Strategy Committee Report :

Under Five Ideas for Top-Priority Investment: (University-wide Institute for) Integrative Data Science and its Mathematical Foundations and Neuroscience, from Molecules to Mind

Under Five Additional Priority Ideas: Computer Science, Conquering Cancer, Precision Medicine, Regenerative Medicine

QT:{{”
Mark Gerstein — a professor of biomedical informatics— similarly emphasized the value of a new data science institute that would integrate Yale’s science campuses and discourage research “silos.” …
Another concern is establishing the specific role of the institute amid the various departments and programs at Yale that perform data science research, Gerstein said. For example, he said, Yale’s new Center for Biomedical Data Science, which Gerstein co-directs, might eventually be folded into the proposed institute.
“}}

Carl Zimmer To Speak At Bio-IT World, Tackle Heredity, Genes, And How Our Understanding Of The Two Is Changing – Bio-IT World

May 11, 2018

http://www.bio-itworld.com/2018/05/09/carl-zimmer-to-speak-at-bio-it-world-tackle-heredity-genes-and-how-our-understanding-of-the-two-is-changing.aspx

QT:{{”
“It was a huge amount of fun watching them take that raw data and put it through their own pipelines,” Zimmer told me, but he also felt uncomfortable pointing out discrepancies to the scientists he worked with. “I still remember, I was sitting down with Chris Mason at Weill Cornell. He and his students were so enthusiastically going through their findings with me… and they showed me, among other things, how many SNPs I had. Not too long beforehand I’d gone through the same experience with Mark Gerstein and his team at Yale, and their numbers for my SNPs were off by hundreds of thousands. … It was a little awkward with Chris, but I just said, ‘Hey, I got a very different number from Mark Gerstein,’ and Chris just shrugged and said, ‘Oh yeah, that happens.’”

It turns out, there’s a lot about our current understanding of our genes and how we pass them on that isn’t perfectly clear cut. “}}

UP CLOSE: Ahead of STEM report, Yale takes stock | Yale Daily News

April 29, 2018

QT:{{”
Mark Gerstein, a professor of biomedical informatics, molecular biophysics and biochemistry and computer science, lauded the committee’s creation. It is crucial, he said, to determine a strategy for science at Yale, as opposed to just narrow “tactics,” like specific programs or buildings.

“If we want to maintain our strength as a university — not just in the sciences — we really need to field a full team,” Gerstein said. “It’s like a football team — you can’t win the Super Bowl if you don’t have all the different positions.”


Gerstein suggested that Yale’s location in New Haven also serves as a “major factor,” potentially hindering success in faculty recruitment. Especially when compared to California, Boston or New York, living in New Haven may be less appealing to potential professors, he added. “}}

Written by Amy Xiong
Photos by Daniel Zhao
Graphics by Rebecca Goldberg
Published on April 27, 2018

Put your email inbox on a low-spam diet : Naturejobs Blog

April 15, 2018

Put your email inbox on a low-spam diet by @j_perkel
http://blogs.Nature.com/naturejobs/2018/04/11/clean-your-email-inbox-with-a-low-spam-diet/ #Email hygiene for the researcher – ie how to escape fake conference & journal invites + #spam calendar invites
QT:{{”

The practice of publishing their email addresses on journal articles and university web sites makes research academics ready targets for email spammers. Spam, Clemons insists, is not merely a nuisance but a time-sink. Mark Gerstein, a professor of biomedical informatics at Yale University in New Haven, Connecticut, estimates that maybe a quarter of the 200-or-so messages he receives in a day are important. “I spend many, many, many hours a week, days a week probably, going through my correspondence,” he says.

Gerstein, for instance, uses a multi-tiered approach to triage his correspondence, relying on Gmail filters, labels, and artificial intelligence. Gerstein has a whitelist — a list of ‘approved’ email addresses. Messages from those addresses are automatically routed to his inbox, where they receive the highest priority. New senders can get on that list by placing a special keyword (available on his web site) in the subject line of their message — which is how I was able to contact him.

Below that top tier are departmental messages, messages from mailing lists, and the like. At the very bottom is the obvious spam, the stuff that gets picked up by Google’s spam-detection algorithms. And in the middle is what Gerstein calls ‘almost-spam’ — messages from predatory journals and conferences, spam invitations to join editorial boards, and even spam calendar invites, which automatically add themselves to his calendar and clog up his schedule.

Gerstein advises researchers to use multiple email addresses in dealing with journals, vendors, and the like. Then, by funneling those messages to a single inbox, one can sort the messages by account and prioritize them accordingly.

Gmail is particularly useful for this purpose, Gerstein notes. Suppose you have the address ‘janesci@gmail.com’. Google allows users to modify their addresses by placing a plus sign and additional text between the username and the at-symbol — for instance,
‘janesci+amazon@gmail.com’ and ‘janesci+ebay@gmail.com’. These messages all go to the original address, but users can sort their messages based on the specific address used.

“You can use that quite powerfully to create unique addresses for all sorts of things, and to filter your email on the basis of that,” Gerstein says.

Still, Gerstein admits, spam inevitably falls through the cracks. How to spot it?
“}}

Yale Daily News article about the new Yale Center for Biomedical Data Science (CBDS)

February 10, 2018

Yale establishes biomedical data science center
https://yaledailynews.com/blog/2018/02/09/yale-establishes-biomedical-data-science-center

QT:{{
“The field of data science has become particularly relevant in the biomedical realm — in genomic sequencing, imaging data, patient record data, data on molecules like nucleotides, proteins and metabolites and wearable personal health devices,” Gerstein said. “All of these create data streams that are growing particularly large, and there’s a lot of value in mining and integrating these different data streams.” …

“Although this initiative was started by the medical school, it is meant for the whole campus,” Gerstein said. “We want undergraduates to do research and take courses in biomedical data science — and to be engaged in this center.”
“}}