The Simple Mathematical Law That Financial Fraudsters Can’t Beat
December 14, 2023How to Improve Short-Term Memory – The New York Times
December 13, 2023Article for you
December 13, 2023What Can You Do With an Einstein?
Earlier this year, mathematicians discovered a unique shape. Now do-it-yourselfers have found ingenious ways to put it to use.
https://www.nytimes.com/2023/12/10/science/mathematics-tiling-einstein.html
Some claim human lifespans can be lengthened indefinitely
December 11, 2023https://www.economist.com/technology-quarterly/2023/09/25/some-claim-human-lifespans-can-be-lengthened-indefinitely
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There is a story about a blues musician who, when questioned on his 100th birthday about his decades of smoking and drinking, responded that if he’d known he was going to live so long, he’d have taken better care of himself. Bryan Johnson is that apocryphal bluesman’s polar opposite. He has been taking care of himself for years to a degree as remarkable, in its way, as the deepest devotion to bourbon and bad choices. …
The daily regime which he and his many doctors have devised makes life in Biosphere 2 look sybaritic. A kilogram of vegetables, all before 11am, rigorous workouts lasting 45-60 minutes, and 100 pills, including metformin and rapamycin. His vital functions are subjected to the sort of continuous scrutiny more usually associated with laboratory animals. He says he is ageing at 69% of the normal rate. Mr Johnson, who has been described as the most measured man in the world, can afford the team of medics, trainers and dieticians who minister to him because selling Braintree, an electronic-payments company which he founded, left him with a net worth of more than $100m. For mere mortals, however, a range of less intensive options are available.
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Regression Toward the Mean: An Introduction with Examples
December 11, 2023The Key Role of Product Management in Startups with Dan Cohen (Accomplio) – YouTube
December 11, 2023Eating fewer calories can ward off ageing
December 11, 2023https://www.economist.com/technology-quarterly/2023/09/25/eating-fewer-calories-can-ward-off-ageing
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Take the mtorc1 pathway. The complex of proteins which gives it its name first came to attention because an immune suppressant called rapamycin has a strong effect on it: hence “mechanistic target of rapamycin complex 1”. That gives no real clue, however, to the fact that the signalling pathway in which mtorc1 sits is a complex set of controls and feedbacks designed to regulate metabolism in response both to the availability of nutrients …
The ambit of this regulatory power is broad; it influences the rate at which cells break down damaged internal structures (“autophagy”), the balance of their protein content (“proteostasis”) and the reproduction of their mitochondria, components responsible for turning the calories it receives into a form of energy its proteins can use. Autophagy, proteostasis and mitochondrial reproduction are three more of the 12 hallmarks of aging.
What is more, rapamycin, the effects of which give mtorc1 its name, turns out to lengthen the lives of lab animals even though it curbs their immune responses. …There is thus a search for “rapalogs” which provide the benefits of a tuned-up mtorc1 pathway without so many costs.
Another pathway which calorie-restriction studies have marked out as promising is named after a protein called ampk (don’t ask). This regulates the production of ATP, a small energy-carrying molecule produced in mitochondria. When atp levels fall, the ampk pathway increases a cell’s sensitivity to insulin.
Metformin, a drug used to treat type-2 diabetes, does so by activating the ampk pathway. Like rapamycin, it extends the lifespans of healthy mice.
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