Something Is Very Wrong with Modern Longevity Science | The New Yorker
https://www.newyorker.com/magazine/2026/07/06/morbid-saul-justin-newman-book-review-eat-your-ice-cream-ezekiel-j-emanuel
Posts Tagged ‘aging’
Something Is Very Wrong with Modern Longevity Science
August 23, 2026How Did Maria Branyas Morera, Who Was the World’s Oldest Person, Live So Long? – The New York Times
September 27, 2025Do longevity drugs work?
August 15, 2025A Common Assumption About Aging May Be Wrong, Study Suggests – The New York Times
July 6, 2025https://www.nytimes.com/2025/06/30/well/live/aging-inflammation-lifespan-environment.html
A Common Assumption About Aging May Be Wrong, Study Suggests
Experts have long pointed to inflammation as a natural part of getting older. But a new paper suggests it might be more a product of our environment.
June 30, 2025
The Abstract: 8 Compounds That Target Aging
March 18, 2025Guarente, L., Sinclair, D. A., & Kroemer, G. (2024). Human trials exploring anti-aging medicines. Cell Metabolism, 36(2), 354–376. https://doi.org/10.1016/j.cmet.2023.12.007
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00458-8
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In a recent issue of Cell Metabolism, Guarente co-authored a review article about human trials exploring compounds that target pathways and mechanisms of aging along with David Sinclair, Ph.D., one of Dr. Guarente’s postdoctoral mentees and now a professor of genetics at Harvard Medical School, and Guido Kroemer, M.D., Ph.D., a professor at the Université Paris Cité. Guarente and his colleagues focus on eight drugs and compounds: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories.
These interventions made the list for four reasons: 1) they’re well-represented in ongoing or completed human clinical trials; 2) they’ve been shown to slow aging in preclinical studies; 3) they’re thought to be sufficiently safe for long-term use in humans; and 4) they work by targeting the hallmarks of aging.
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