https://www.pnas.org/doi/10.1073/pnas.0701361104?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed QT:{{” We find that essential human genes are likely to encode hub proteins and are expressed widely in most tissues. This suggests that disease genes also would play a central role in the human interactome. In contrast, we find that the vast majority of disease genes are nonessential and show no tendency to encode hub proteins, and their expression pattern indicates that they are localized in the functional periphery of the network. “}}
Goh, K., Cusick, M. E., Valle, D., Childs, B., Vidal, M., & Barabási, A. (2007). The human disease network. Proceedings of the National Academy of Sciences, 104(21), 8685–8690.
https://doi.org/10.1073/pnas.0701361104
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