Posts Tagged ‘cmppgene’

BRAF pseudogene and cancer development

April 17, 2015

BRAF #Pseudogene Functions as a Competitive Endogenous RNA; [Shows it] induces Lymphoma [after alteration, in mice]

Cell. 2015 Apr 9;161(2):319-32. doi: 10.1016/j.cell.2015.02.043. Epub 2015 Apr 2.

Karreth FA1, Reschke M1, Ruocco A1, Ng C1, Chapuy B2, Léopold V1, Sjoberg M3, Keane TM3, Verma A4, Ala U1, Tay Y1, Wu D5, Seitzer N1, Velasco-Herrera Mdel C3, Bothmer A1, Fung J1, Langellotto F6, Rodig SJ7, Elemento O4, Shipp MA2, Adams DJ3, Chiarle R8, Pandolfi PP9.

Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments
demonstrated that pseudogenes contribute….

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators : Nature : Nature Publishing Group

February 21, 2015

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators Reconstructed #evolution across 8 species

Daniel W. Bellott,
Jennifer F. Hughes,

Richard A. Gibbs,
Richard K. Wilson
& David C. Page

Nature 508, 494–499 (24 April 2014) doi:10.1038/nature13206

Circle of life

November 15, 2014

the "circle of life"

Volume 24, Issue 6, pR238–R240, 17 March 2014

Evolution: Dynamics of De Novo Gene Emergence

Rafik Neme
Diethard Tautz


A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics | eLife

June 22, 2014

We identify an lncRNA pseudogene, Lethe (named after the mythological river of forgetfulness, for its role in negative feedback), which is expressed in response to proinflammatory cytokines TNFα and IL-1β, and the anti-inflammatory agent, dexamthasone, but is not responsive to microbial components, and is primarily found on the chromatin. Lethe is regulated by RelA, independent of pseudogene family members and proximal genes. Additionally, Lethe is dramatically downregulated in aged spleen. Finally, Lethe binds directly to RelA to inhibit NF-κB DNA binding activity. These findings suggest that Lethe may function as a novel negative regulator of NF-κB, to help fine tune the inflammatory response.

A mammalian #pseudogene #lncRNA at the interface of inflammation… Lethe may down-regulate NF-kB via binding to RelA

No use of Gencode pgenes !

PLOS ONE: Burst of Young Retrogenes and Independent Retrogene Formation in Mammals

April 19, 2014

Burst of Young Retrogenes…in Mammals. Discusses much
retro-transposition ~40 Mya, relevant to proc. #pseudogenes

Also, ref #11 provides more detail on this.

age distribution of repeats

March 24, 2014

From the following article:
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium
Nature 409, 860-921(15 February 2001)

Alu age distribution