http://www.nature.com/nature/journal/v512/n7515/full/512374a.html The Nature N&V
Posts Tagged ‘cmptxn’
YaleNews | Evolution used similar molecular toolkits to shape flies, worms, and humans
August 30, 20142014 Release: Scientists looking across human, fly and worm genomes find shared biology
August 30, 2014GenomeWeb Daily News | Arrays | GenomeWeb
August 27, 2014plant phylotypic stage
February 21, 2014single cell trascriptomes and WGCNA
January 2, 2014Nature. 2013 Aug 29;500(7464):593-7. doi: 10.1038/nature12364. Epub 2013 Jul 28.
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing.
Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G.
QT:{{”
…We report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing…. By weighted gene co-expression network analysis, we find that each developmental stage can be delineated concisely by a small number of functional modules of co-expressed genes. This result indicates a sequential order of transcriptional changes in pathways of cell cycle, gene regulation, translation and metabolism, acting in a step-wise fashion from cleavage to morula. Cross-species comparisons with mouse pre-implantation embryos reveal that the majority of human stage-specific modules (7 out of 9) are notably preserved, but developmental specificity and timing differ between human and mouse. Furthermore, we identify conserved key members (or hub genes) of the human and mouse networks.
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This paper mentions finding 350 pseudogenes in C. elegans
August 23, 2013The Vast, Conserved Mammalian lincRNome
March 2, 2013paper comparing human and mouse lncRNAs
The Vast, Conserved Mammalian lincRNome
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002917
Developmental Milestones Punctuate Gene Expression in the Caenorhabditis Embryo
February 19, 2013http://www.cell.com/developmental-cell/abstract/S1534-5807%2812%2900142-6
Michal Levin, Tamar Hashimshony, Florian Wagner, and Itai Yanai.
Developmental milestones punctuate gene expression in the
Caenorhabditis embryo. Developmental Cell (May 2012)
Nice disussion of the phylotypic stage .
Figure 4S-E have stage mapping between dmel and celegans
linkstream2 microblog 