Limitation to 81 characters
https://nexus.od.nih.gov/all/2010/10/01/does-the-application-title-have-a-maximum-length-2/
Limitation to 81 characters
https://nexus.od.nih.gov/all/2010/10/01/does-the-application-title-have-a-maximum-length-2/
A New Initiative on Precision Medicine
http://www.nejm.org/doi/full/10.1056/NEJMp1500523 Notable: focus on #cancergenomics & mention of endophenotypes & #QS data
Francis S. Collins, M.D., Ph.D., and Harold Varmus, M.D.
N Engl J Med 2015; 372:793-795February 26, 2015DOI: 10.1056/NEJMp1500523
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“These features make efforts to improve the ways we anticipate, prevent, diagnose, and treat cancers both urgent and promising. Realizing that promise, however, will require the many different efforts reflected in the President’s initiative. To achieve a deeper understanding of cancers and discover additional tools for molecular diagnosis, we will need to analyze many more cancer genomes. ….
The cancer-focused component of this initiative will be designed to address some of the obstacles that have already been encountered in “precision oncology”: unexplained drug resistance, genomic
heterogeneity of tumors, insufficient means for monitoring responses and tumor recurrence, and limited knowledge about the use of drug combinations.
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The initiative’s second component entails pursuing research advances that will enable better assessment of disease risk, understanding of disease mechanisms, and prediction of optimal therapy for many more diseases, with the goal of expanding the benefits of precision medicine into myriad aspects of health and health care.
The initiative will encourage and support the next generation of scientists to develop creative new approaches for detecting, measuring, and analyzing a wide range of biomedical information — including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters. Many possibilities for future applications spring to mind: today’s blood counts might be replaced by a census of hundreds of distinct types of immune cells; data from mobile devices might provide real-time monitoring of glucose, blood pressure, and cardiac rhythm; genotyping might reveal particular genetic variants that confer protection against specific diseases…
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BD2K funded programs so far…
https://datascience.nih.gov/bd2k/funded-programs/enhancing-training/institutional-grants
NIGMS Comp Bio & Bioinfo funded predoctoral programs
http://www.nigms.nih.gov/Training/InstPredoc/Pages/PredocInst-Bioinformatics.aspx
THE NLM funded Biomedical Informatics training programs
https://www.nlm.nih.gov/ep/GrantTrainInstitute.html#5
Disappearing Young Scientists http://on.wsj.com/1v4GvUk Michael Levitt on implications of #budget cuts for starting researchers HT @oselsayed
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What’s behind the shortage? Mr. Daniels suggests several reasons, including longer postdoctoral training; a system of applications, demonstrable data and peer review, and a shift in research costs to universities—which typically narrows awards to seasoned, tenured researchers. But perhaps the simplest explanation came from Nobel laureate Michael Levitt of Stanford, who said last year that senior scientists were once able to renew their existing grants and let young scientists compete for unawarded grant money. Now after budget cuts, older scientists are competing “against the kids,” and usually winning.
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n 2005, just as Mr. Silver’s referral income from the Weitz firm began to balloon, records show that he directed a state grant worth $250,000 to Dr. Taub for asbestos research, ostensibly related to the Sept. 11, 2001, terrorist attacks. In October 2006, Dr. Taub wrote to Mr. Silver to request another $250,000 grant. A few months later, the money arrived.
Both times, the plans submitted by Dr. Taub’s center said the money would go toward studying the general treatment of mesothelioma, making only passing reference to those who may have been exposed to asbestos after the attacks on the World Trade Center.
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For his part, Dr. Taub served as an expert witness for the Weitz firm as recently as a 2013 case in federal court in Pennsylvania. Legal records show that his rate for working on the case was $1,750 per hour, plus $7,500 per day for testimony when overnight travel was required.
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http://www.nytimes.com/2015/01/25/nyregion/sheldon-silvers-link-to-a-bonanza-and-a-cancer.html
Here is a link for some helpful information on the new NIH format for biosketches:
Nice overview of the programs
http://www.courant.com/health/hc-jackson-laboratory-20141002-story.html
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The facility is funded in part by $291 million from the state through a legislative act passed three years ago, largely along party lines. In general, Democrats backed the plan by Gov. Dannel P. Malloy’s administration, and Republicans said it was too much money in exchange for 300 jobs over the course of a decade.
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About 150 people work at the Farmington location, most of them hired in the past 16 to 18 months,said Charles Lee, director of the Jackson Laboratory for Genomic Medicine.
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Last week, as Lee arrived by plane in Seoul, Korea, to check on a collaborative research project there, he was greeted at the airport by media reporting on a recent announcement that Lee is a 2014 Thomson Reuters Citation Laureate, meaning that he is a strong contender this year for a Nobel Prize in physiology or medicine. Nobel winners will be announced Oct. 6.
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The lab is headquartered in Bar Harbor, Maine, and it has another location in Sacramento, Calif. All told, the laboratory has an annual budget of $262.4 million for fiscal year 2014 and employs more than 1,500 people, mostly in Maine.
Much of its revenue — $165.3 million — comes from the JAX Mice & Clinical Research Services through its sale of mice to other researchers. Jackson Laboratory in Bar Harbor ships more than 3 million mice annually to researchers around the globe, Lee said.
The lab also received $69.6 million in public support, including grants and contracts in fiscal year 2014. The rest of its budget is funded by contributions and other sources.
In 10 years or so, the Farmington facility could become a $70 million-to-$75 million operation, said Mike Hyde, a spokesman for The Jackson Laboratory.
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Jackson is partnering with various Connecticut hospitals and universities, too. Lee has reached out to researchers at Quinnipiac, Wesleyan and Yale.
“I already have a collaboration that’s funded by the NIH with Mark Gerstein, a full professor at Yale University,” Lee said. “I’m developing ties with Rick Lifton, who is the head of genetics at Yale.”
Perhaps the closest academic relationship, in proximity and in collaboration, is between Jackson and both the UConn Health Center and UConn School of Medicine.
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