Posts Tagged ‘human’

A New Theory on How Neanderthal DNA Spread in Asia

February 27, 2015

New Theory on How #Neanderthal DNA Spread in Asia by @carlzimmer 2nd pulse of mating w/ humans v better preservation

NA12878 high confidence calls

February 20, 2014

Integrating genotype from many callers & indication of where they differ. Might be useful for the personal diploid genome.

Distributed variation prefers the golden mean – Gene Expression |

September 16, 2013

#Variation prefers the golden mean: Moderate selection involves many loci v weak & strong, few via @drbachinsky
Moderate selection, many loci; Weak or strong selection, few loci.

Gene intolerance scores in a Plos Gen paper

August 26, 2013
This paper discusses gene intolerance score — very similar to depletion of common polymorphisms. They don’t analyze non-coding regions — this is using exome data only. Blue for tolerant and red for intolerant (see Figure 1) .