New Theory on How #Neanderthal DNA Spread in Asia by @carlzimmer http://www.nytimes.com/2015/02/20/science/a-new-theory-on-how-neanderthal-dna-spread-in-asia.html 2nd pulse of mating w/ humans v better preservation
Posts Tagged ‘human’
A New Theory on How Neanderthal DNA Spread in Asia
February 27, 2015NA12878 high confidence calls
February 20, 2014Integrating genotype from many callers & indication of where they differ. Might be useful for the personal diploid genome.
http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.2835.html
Distributed variation prefers the golden mean – Gene Expression | DiscoverMagazine.com
September 16, 2013#Variation prefers the golden mean: Moderate selection involves many loci v weak & strong, few http://bit.ly/18MgU6p via @drbachinsky
Moderate selection, many loci; Weak or strong selection, few loci.
http://blogs.discovermagazine.com/gnxp/2013/09/distributed-variation-prefers-the-golden-mean/#.UjJTHmSG1MF
Gene intolerance scores in a Plos Gen paper
August 26, 2013http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003709#pgen-1003709-g006
This paper discusses gene intolerance score — very similar to depletion of common polymorphisms. They don’t analyze non-coding regions — this is using exome data only. Blue for tolerant and red for intolerant (see Figure 1) .
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