Posts Tagged ‘i0grc14’

PLOS Computational Biology: Target Essentiality and Centrality Characterize Drug Side Effects

August 7, 2014

Target Essentiality… Characterizes Drug Side Effects – much more so than the total number of targets for a #drug

Activating Mutations Cluster in the “Molecular Brake” Regions of Protein Kinases and Do Not Associate w ith Conserved or Catalytic Residues

August 7, 2014

Activating Mutations Cluster in… Regions of… #Kinases & Do Not Associate with Conserved or Catalytic Residues

related to Kin-Driver – a database of driver mutations, which can be used as a gold std in driver predictions