Segal cites: Determinants of TF binding outside the core binding site http://genome.cshlp.org/content/early/2015/06/05/gr.185033.114.abstract Large-scale measurement of affinity #ICSG2015
Posts Tagged ‘i0isgc’
Structural insights into mis-regulation of protein kinase A in human tumors
June 8, 2015Hendrickson cites: Structural insights into mis-regulation of PKA in…tumorshttp://www.pnas.org/content/112/5/1374 SNV stops reg. domain binding #ICSG2015
In other case showed recurring DnaJ–PKA fusion didn’t have coding effect but non-coding effect on promotor
vol. 112 no. 5
1374–1379, doi: 10.1073/pnas.1424206112
Structural insights into mis-regulation of protein kinase A in human tumors
Jonah Cheunga,1,
Christopher Gintera,
Michael Cassidya,
Matthew C. Franklina,
Michael J. Rudolpha,
Nicolas Robineb,
Robert B. Darnellb,c,d, and
Wayne A. Hendricksona,e,1
PLOS Computational Biology: Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies
June 7, 2015Evolution of…Enzyme Functions w/in Structural…Superfamilies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002403 Most changes involve substrates rather than chemistry
develops functional change matrix…
based on 276 fams
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