Stumbled onto this paper. Thought the conclusion that Europeans were more cold-sensitive due to TRPM8 was quite counter-intuitive – but interesting nevertheless
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007298
cold receptor
https://www.nytimes.com/interactive/2021/health/coronavirus-variant-tracker.html
D614G
N501Y
E484K
B.1.1.7, B.1.351
QT:{{”
The D614G mutation emerged in eastern China early in the pandemic and then quickly spread around the world, displacing other coronaviruses that did not have the mutation.
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The D614G mutation is thought to make the coronavirus more infectious, but it does not appear to make the disease more severe or help the virus escape vaccines.
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The N501Y mutation arose independently in several variants of concern, including the B.1.1.7, B.1.351 and P.1 lineages.
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The mutation is near the tip of the coronavirus spike, where it seems to change the shape of the protein to be a tighter fit with human cells.
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The E484K mutation arose independently in multiple lineages, including B.1.351 and P.1. Scientists are also concerned that the mutation was recently found in some samples from the B.1.1.7 lineage from Britain. …
The mutation occurs near the top of the coronavirus spike, where it alters the shape of the protein. This change may help the spikes evade some types of coronavirus antibodies.
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b117 or b.1.1.1.7 mutation
D614G mutation
https://www.nytimes.com/2020/11/24/world/covid-mutation.html
Evidence Builds That an Early Mutation Made the Pandemic Harder to Stop
Scientists were initially skeptical that a mutation made the coronavirus more contagious. But new research has changed many of their minds.
What to Know About the Covid Antibody Drugs That Could Help Many
Here’s information about who these therapies can help, how much they cost and how to find out if you can get them where you live.
https://www.nytimes.com/2020/12/23/health/coronavirus-antibody-drugs.html
Lilly’s neutralizing antibody bamlanivimab
Regeneron’s Casirivimab and Imdevimab Antibody Cocktail
Sequence Variants in TAAR5 & Other Loci Affect Human Odor Perception & Naming https://www.cell.com/current-biology/fulltext/S0960-9822(20)31343-9 A variant in TAAR5 affects the perception of fish odor. Interesting to consider in relation to pseudogenization of the olfactory receptors
While about half of human odorant receptors are thought to be pseudogenes with loss-of-function, the Decode Genetics folks show that some sequence variants in odorant receptor genes are not
loss-of-function.
D614G mutation
https://www.nytimes.com/2020/11/24/world/covid-mutation.html
Evidence Builds That an Early Mutation Made the Pandemic Harder to Stop
Scientists were initially skeptical that a mutation made the coronavirus more contagious. But new research has changed many of their minds.
https://www.nytimes.com/live/2020/11/09/world/covid-19-coronavirus-live-updates QT:{{”
The Food and Drug Administration has granted emergency authorization of a Covid-19 treatment made by the American pharmaceutical company Eli Lilly that was given to Chris Christie, the former New Jersey governor, when he was infected with the coronavirus.
The authorization, announced on Monday, applies only to people newly infected with the virus, and the agency said it should not be used in hospitalized patients. The treatment is approved for people 12 and older who have tested positive and are at risk for developing a severe form of Covid-19 or being hospitalized for the condition. That includes people who are over 65 and obese, the agency said — a key group that early studies have shown can benefit the most from the treatment.
Eli Lilly said that its treatment, called bamlanivimab, should be administered as soon as possible after a positive test, and within 10 days of developing symptoms.
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bamlanivimab
