Posts Tagged ‘keyabbrev’
Physics-Informed Neural Networks: An Application-Centric Guide | by Shuai Guo | Towards Data Science
November 2, 2024The battle over the trillion-dollar weight-loss bonanza
October 4, 2024https://www.economist.com/business/2024/03/04/the-battle-over-the-trillion-dollar-weight-loss-bonanza glp-1 agonists
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The drugs’ biggest impact so far, though, has been on their makers. Sales of Wegovy, developed by a Danish firm called Novo Nordisk, swelled from $876m in 2022 to $4.5bn in 2023. The company expects double that this year. Zepbound, introduced in America in November by Eli Lilly, an American pharma giant, is expected to generate $2.9bn in sales in its first full year. Bloomberg, a data provider, predicts that by 2030 yearly sales of weight-loss medications will reach a staggering $80bn, putting them among the biggest classes of drugs in history. Eli Lilly and Novo Nordisk are expected to corner more than 90% of the market (see chart 2).
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How 3M Discovered, Then Concealed, the Dangers of Forever Chemicals | The New Yorker
August 27, 2024https://www.newyorker.com/magazine/2024/05/27/3m-forever-chemicals-pfas-pfos-toxic
Lerner, S. (2024, May 20). How 3M discovered, then concealed, the dangers of forever chemicals. The New Yorker.
https://www.newyorker.com/magazine/2024/05/27/3m-forever-chemicals-pfas-pfos-toxic
the horror of PFOS
Golden ratio – Wikipedia
May 2, 2024https://en.wikipedia.org/wiki/Golden_ratio
1.618033988749
Adjusted EBITDA Example | A Simple Model
March 12, 2024Has Alzheimer’s met its match? – ScienceDirect
February 29, 2024https://www.sciencedirect.com/science/article/abs/pii/S0262407923009429?via%3Dihub
New Scientist
Volume 258, Issue 3440, 27 May 2023, Pages 14-15
Has Alzheimer’s met its match?
Clare Wilson
What is litecoin?| CMC Markets
February 18, 2024The Seven Tech Stocks Driving the S&P 500 to New Highs – The New York Times
January 23, 2024https://www.nytimes.com/interactive/2024/01/22/business/magnificent-seven-stocks-tech.html
Alphabet (GOOGL), Apple (AAPL), Amazon (AMZN), Meta Platforms (META), Microsoft (MSFT), Nvidia (NVDA) and Tesla (TSLA)
Eating fewer calories can ward off ageing
December 11, 2023https://www.economist.com/technology-quarterly/2023/09/25/eating-fewer-calories-can-ward-off-ageing
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Take the mtorc1 pathway. The complex of proteins which gives it its name first came to attention because an immune suppressant called rapamycin has a strong effect on it: hence “mechanistic target of rapamycin complex 1”. That gives no real clue, however, to the fact that the signalling pathway in which mtorc1 sits is a complex set of controls and feedbacks designed to regulate metabolism in response both to the availability of nutrients …
The ambit of this regulatory power is broad; it influences the rate at which cells break down damaged internal structures (“autophagy”), the balance of their protein content (“proteostasis”) and the reproduction of their mitochondria, components responsible for turning the calories it receives into a form of energy its proteins can use. Autophagy, proteostasis and mitochondrial reproduction are three more of the 12 hallmarks of aging.
What is more, rapamycin, the effects of which give mtorc1 its name, turns out to lengthen the lives of lab animals even though it curbs their immune responses. …There is thus a search for “rapalogs” which provide the benefits of a tuned-up mtorc1 pathway without so many costs.
Another pathway which calorie-restriction studies have marked out as promising is named after a protein called ampk (don’t ask). This regulates the production of ATP, a small energy-carrying molecule produced in mitochondria. When atp levels fall, the ampk pathway increases a cell’s sensitivity to insulin.
Metformin, a drug used to treat type-2 diabetes, does so by activating the ampk pathway. Like rapamycin, it extends the lifespans of healthy mice.
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