Posts Tagged ‘jl’

The Longevity Secrets Helping Athletes Blow Past the Limits of Age

May 8, 2026

sports: money, data & fun

QT:{{”
Partly what’s driving the changes is the size of the fortunes at stake. The typical salary for an N.B.A. player is now close to $12 million a year. Career reserves — not just the stars — often employ their own trainers, dietitians, chefs and assortments of recovery gizmos. When a member of James’s inner circle claimed in 2018 that James was spending about $1.5 million a year on caring for his body, it accelerated an arms race across sports, helping to power a consumer-tech boom that has already trickled down to the $314 billion market for wearable devices that track things like sleep and heart rate.
….
Today’s pros are awash in data, and the ones who learn to sort out the signals from the noise stand the best chance of prolonging their careers.

Most of that data is still noise. “Just because you can measure it” — using wearable devices, for example — “doesn’t mean it’s meaningful, durable, that kind of thing,” says Dr. Michael Joyner, a specialist in the physiology of elite athletes at the Mayo Clinic. The most useful data so far, he says, speaking for himself and not the clinic, relates to “load management”: monitoring exertion, particularly by older players, to reduce the risk of fatigue-related, noncontact injuries. …
Since 2021, the N.B.A. has run an in-house incubator called Launchpad that collaborates annually with five small start-ups whose projects might prove useful to the league — an A.I. tool to track officiating, say, or a device that converts gameplay into haptics for
sight-impaired fans.
….

As part of the effort to collect joint and muscle data, every single N.B.A. player, from LeBron to Bronny, now takes a brief “biomechanical assessment” up to four times a year. The assessment room I visited, at the Brooklyn Nets facility, looked like a miniature Marvel movie set — bright space, blank walls, a ring of cameras to capture motion — only this room had two “force plates” built into the floor that help measure applied muscle force.

The assessment covers seven simple movements — various lunges, jumps and timed balances — and produces a player score relative to the rest of the league and the player’s own history.
….
For some athletes, the right biometric data presented in the right context represents “permission to rest,” says Ana Montero, a co-founder of Atlas, a San Francisco-based company that makes brain-wave-scanning, behind-the-ear wearables about the size of Mentos candies. “It’s quantifiable evidence that is showing you: Dude, today — or right now — is not the day. Go to the gym, go for a walk, go for whatever it is. And then coming back and actually seeing that you’ve bounced back.”

The Atlas device gathers several types of data, including
electroencephalography, or EEG, which measures electrical activity in the brain, and galvanic skin response, or G.S.R., which is what a polygraph test measures. That data is sorted into five categories (among them agility, vitality and stress) and then delivered with advice through a smartphone app.
“}}

Concepts, estimation and interpretation of SNP-based heritability – Nature Genetics

February 22, 2026

See Box 1, viz:

QT:{{”

Box 1 Statistical model used in the GREML approach to estimate hS2NP The statistical model used by GREML can be described in its simplest form as y = Wu + e
where y is an n x 1 vector of standardized phenotypes with n equal to the sample size, W = {wij} is an n x m standardized SNP genotype matrix where m is the number of SNPs, u = {ui} is an m x 1 vector of the additive effects of all variants when fitted jointly in the model, u ~ N(0,Iσ2) with I being an identity matrix, u and e is a vector of residuals, e ~ N(0,Iσ2). An equivalent model is….

y=g+e
g ~ N(0,A…)
A=W W’

In practice, A is called the SNP-derived genetic (or genomic) relationship matrix (GRM) and is estimated from the SNP data. The estimate …from GREML can be described as the estimated variance explained by all the SNPs (mσu) or equivalently as the estimated genetic variance by contrasting the phenotypic similarity
between unrelated individuals to their SNP-derived genetic similarity “}}

https://www.nature.com/articles/ng.3941

Yang, J., Zeng, J., Goddard, M. E., Wray, N. R., & Visscher, P. M. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49(9), 1304–1310.
https://doi.org/10.1038/ng.3941

Recent Parkinsons paper from Oxford

December 8, 2025

https://www.nature.com/articles/s41531-025-01214-6

Daily steps are a predictor of, but perhaps not a risk factor for Parkinson’s disease: findings from the UK Biobank – npj Parkinson’s Disease
nature.com

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology | Nature

November 23, 2025

https://www.nature.com/articles/s41586-025-09702-8

Demontis, D., Duan, J., Hsu, Y. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O., . . . Børglum, A. D. (2025). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature.
https://doi.org/10.1038/s41586-025-09702-8

QT:{{”
Common genetic variants associated with the disorder have been identified12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 × 10−6; odds ratios 5.55–15.13) that are implicated in ADHD.
“}}

serotonin & depression

August 28, 2022

https://www.nature.com/articles/s41380-022-01661-0

QT:{{”
For decades, doctors believed ssris operated by boosting levels of serotonin, a chemical which carries signals between neurons in the brain. This supposition was based on the hypothesis that a lack of serotonin causes depression. But a growing number of investigations suggest that theory does not hold water—a conclusion hammered home by a round-up of reviews of such work just published in Molecular Psychiatry.
“}}

https://www.economist.com/science-and-technology/2022/07/20/a-popular-medical-explanation-for-depression-is-rebuffed

SLC6A4 Gene – GeneCards | SC6A4 Protein | SC6A4 Antibody

August 1, 2022

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4

QT:{{”
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
“}}
famous serotonin re-update transporter

foodlab

July 3, 2021

Here’s Kenji’s YouTube channel (almost a million subscribers):

https://www.youtube.com/channel/UCqqJQ_cXSat0KIAVfIfKkVA

His videos are a similar style to his book, where he sometimes talks about science. For example in this video:

https://www.youtube.com/watch?v=U3gvRjIQ6Lo

At the 1:45 mark, he talks about the physics behind selecting tomatoes At the 4:01 mark, he talks about boiling water (volume, heat, etc) in relation to cooking pasta

2020 trends

December 30, 2020

https://i.redd.it/j47226oocy661.png

https://i.redd.it/v78l5due4b561.png

macos – How can I convert .ichat logs to text files? – Ask Different

June 3, 2020

https://apple.stackexchange.com/questions/72987/how-can-i-convert-ichat-logs-to-text-files

QT:{{”
For reference, these are the conversation files located in
~/Library/Messages/Archive.

$ file transcript.ichat
transcript.ichat: Apple binary property list

$ plutil -convert xml1 transcript.ichat
“}}

Lookup Mac Specs By Serial Number, Order, Model & EMC Number, Model ID @ EveryMac.com

June 3, 2020

https://everymac.com/ultimate-mac-lookup/