Posts Tagged ‘paperE’
Scientists find ‘drivers’ of cancer, but warn: Don’t ignore ‘passengers’ | YaleNews
February 23, 2020Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations | GenomeWeb
February 23, 2020Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations _ GenomeWeb.pdf
Pattern Recognition and Machine Learning (Information Science and Statistics): Christopher M. Bishop: 9780387310732: Amazon.com: Books
January 25, 2020https://www.amazon.com/Pattern-Recognition-Learning-Information-Statistics/dp/0387310738
The book has a brief description of hyperparameter fitting using type 2 max likelihood at the start of section 3.5, pages 165-166
Restricted maximum likelihood – Wikipedia
January 25, 2020https://en.wikipedia.org/wiki/Restricted_maximum_likelihood
REML can be used to est. the hyperparameters of a random-effects model
Random effects model – Wikipedia
January 25, 2020what is heritability
October 6, 2017Heritability 501: LDSR-based H2…for the technically minded
http://www.NealeLab.is/blog/2017/9/14/heritability-501-ldsr-based-h2-in-ukbb-for-the-technically-minded Nice overview by @BMNeale lab HT @Sushant211
Nice blog post series explaining heritability.
http://www.nealelab.is/blog/2017/9/13/heritability-101-what-is-heritability
http://www.nealelab.is/blog/2017/9/13/heritability-201-types-of-heritability-and-how-we-estimate-it
Investigating the case of human nose shape and climate adaptation
September 25, 2017The case of human nose shape & climate adaptation
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1006616 Comparing its Qst-Fst statistic w/ that for height & skin color
QT:{{”
“To address the question of whether local adaptation to climate is responsible for nose shape divergence across populations, we use Qst–Fst comparisons to show that nares width and alar base width are more differentiated across populations than expected under genetic drift alone. To test whether this differentiation is due to climate adaptation, we compared the spatial distribution of these variables with the global distribution of temperature, absolute humidity, and relative humidity. We find that width of the nares is correlated with temperature and absolute humidity, but not with relative humidity. We conclude that some aspects of nose shape may indeed have been driven by local adaptation to climate. However, we think that this is a simplified explanation of a very complex evolutionary history, which possibly also involved other non-neutral forces such as sexual selection.”
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