Posts Tagged ‘paperE’

Cancer Genomics and Precision Medicine < Yale Cancer Center

June 2, 2020

Scientists find ‘drivers’ of cancer, but warn: Don’t ignore ‘passengers’ | YaleNews

February 23, 2020

Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations | GenomeWeb

February 23, 2020

Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations _ GenomeWeb.pdf

Passengers, noncoding genome affect how cancers play out | 2020-02-20 | BioWorld

February 23, 2020

Kernel-based whole-genome prediction of complex traits: a review. – PubMed – NCBI

February 8, 2020

Pattern Recognition and Machine Learning (Information Science and Statistics): Christopher M. Bishop: 9780387310732: Books

January 25, 2020

The book has a brief description of hyperparameter fitting using type 2 max likelihood at the start of section 3.5, pages 165-166

Restricted maximum likelihood – Wikipedia

January 25, 2020

REML can be used to est. the hyperparameters of a random-effects model

Random effects model – Wikipedia

January 25, 2020

what is heritability

October 6, 2017

Heritability 501: LDSR-based H2…for the technically minded Nice overview by @BMNeale lab HT @Sushant211

Nice blog post series explaining heritability.

Investigating the case of human nose shape and climate adaptation

September 25, 2017

The case of human nose shape & climate adaptation Comparing its Qst-Fst statistic w/ that for height & skin color

“To address the question of whether local adaptation to climate is responsible for nose shape divergence across populations, we use Qst–Fst comparisons to show that nares width and alar base width are more differentiated across populations than expected under genetic drift alone. To test whether this differentiation is due to climate adaptation, we compared the spatial distribution of these variables with the global distribution of temperature, absolute humidity, and relative humidity. We find that width of the nares is correlated with temperature and absolute humidity, but not with relative humidity. We conclude that some aspects of nose shape may indeed have been driven by local adaptation to climate. However, we think that this is a simplified explanation of a very complex evolutionary history, which possibly also involved other non-neutral forces such as sexual selection.”