https://genomebiology.biomedcentral.com/articles/10.1186/gb4141
Posts Tagged ‘sk’
Rumors of the death of consumer genomics are greatly exaggerated
December 22, 2018Biology Will Be the Next Great Computing Platform
May 11, 2018authoera vs googledoc
November 26, 2017Time-lapse video of the demolition of the Gibbs Building
May 28, 2017Big changes right next store, on Science Hill @Yale
https://www.YouTube.com/watch?v=hbMwpS7JKSQ #Timelapse video of the demolition of the Gibbs Building
Reset your Chrome sync – Chrome Help
October 16, 2016Found this useful after profile corruption – I noticed it deleted & recreated a new profile directory in ~/Library/Application
Support/Google/Chrome/
also useful:
https://support.google.com/chrome/answer/142059?hl=en
virtual credit card
October 7, 2016repository of PDX models of leukemia and lymphoma
April 21, 2016High-throughput DNA sequence data compression
June 12, 2015Private Link by bitly
March 4, 2015Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ, Sunyaev SR. Pooled association tests for rare variants in exon-resequencing studies. American Journal of Human Genetics (2010) 86: 832-838.
February 1, 2015Pooled association tests for rare variants in exon-resequencing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032073 Simulation shows advantage of mult. rarity thresholds
Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ,
Sunyaev SR. Pooled association tests for rare variants in
exon-resequencing studies. American Journal of Human Genetics (2010)
86: 832-838.
SUMMARY
Multiple studies indicate strong association between rare variants and
resulting phenotype. This paper describes a population-genetics
simulation framework to study the influence of variant allele
frequency on the corresponding phenotype. In a prior study, causal
relationship between variants and phenotype was resolved by performing
association test on set of variants having allele frequency below a
fixed threshold. However, here it is observed that simulation
frameworks based on a variable allele frequency threshold provide
higher accuracy in association test compared to the fixed allele
frequency model. In addition, inclusion of predicted functional
effects of variants (Polyphen-2 scores) increases the accuracy of the
variable frequency threshold model. Overall, this paper describes a novel methodology, which can be
used to explore the association between rare variants and various
diseases.
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