Posts Tagged ‘ds’
TWiEVO 9: How to crash your gene drive
July 5, 2016
Hosts: Nels Elde and Vincent Racaniello
Guest: Jim Bull
Nels and Vincent speak with Jim Bull about the results of genetic models which suggest that the evolution of inbreeding in response to lethal gene drive might make population control difficult to achieve.
#Bike lanes are a sound public health investment
http://www.reuters.com/article/us-health-costbenefit-bike-lanes-idUSKCN11Z23A Each $1.3K for NYC provides 1 additional QALY for city residents
….But perhaps non-riders benefit more than riders (who are at risk for injury) cc @dspakowicz
New study of the economics of adding more bikes to NYC (ironically published in the journal “injury prevention”).
Every $1,300 New York City invested in building bike lanes in 2015 provided benefits equivalent to one additional year of life at full health over the lifetime of all city residents, according to a new economic assessment.
That’s a better return on investment than some direct health treatments, like dialysis, which costs $129,000 for one
quality-adjusted life year, or QALY, said coauthor Dr. Babak Mohit of the Mailman School of Public Health at Columbia University in New York.
Painting unprotected bike lanes into roads may not reduce injury and death, she said.
quick video for visualizing the power of kernels in SVM
Dara sharing http://www.nejm.org/doi/full/10.1056/NEJMe1516564 Deems #datascientists as “research parasites,” using another’s data for their own ends via @dspakowicz
“A second concern held by some is that a new class of research person will emerge — people who had nothing to do with the design and execution of the study but use another group’s data for their own ends, possibly stealing from the research productivity planned by the data gatherers, or even use the data to try to disprove what the original investigators had posited. There is concern among some front-line researchers that the system will be taken over by what some researchers have characterized as “research parasites.””
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells : Nature Biotechnology : Nature Publishing GroupNovember 14, 2015
Heterogeneity in #singlecell RNAseq…hidden subpopulations by @OliverStegle lab http://www.nature.com/nbt/journal/v33/n2/full/nbt.3102.html scLVM corrects for cell cycle phase
Buettner, Florian, Kedar N. Natarajan, F. Paolo Casale, Valentina
Proserpio, Antonio Scialdone, Fabian J. Theis, Sarah A. Teichmann,
John C. Marioni, and Oliver Stegle. "Computational analysis of
cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals
hidden subpopulations of cells." Nature biotechnology 33, no. 2
Human Genetics Shape the Gut #Microbiome
http://www.cell.com/abstract/S0092-8674%2814%2901241-0 A particular family of firmicutes is highly heritable & correlated w/ BMI
Goodrich, J.K., Waters, J.L., Poole, A.C., Sutter, J.L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J.T., et al. (2014). Human Genetics Shape the Gut Microbiome. Cell 159, 789–799.