Diphenhydramine-induced toxic psychosis – PubMed

May 28, 2026

https://pubmed.ncbi.nlm.nih.gov/3718632/
QT:{{” A 24-year-old man presented to the emergency department with acute anticholinergic symptoms, hallucinations, and bizarre behavior following a large ingestion of diphenhydramine (Benadryl). “}}

benadryl can cross BBB & cause delusions