Posts Tagged ‘drugtarget’

Teams of AI agents boost speed of research

May 29, 2026

https://www.nature.com/articles/d41586-026-01596-4

QT:{{” In one experiment, Natarajan and his colleagues used Google’s Co-Scientist to look for approved drugs that could be repurposed to treat a form of blood cancer called acute myeloid leukaemia1. The system identified a list of candidate drugs, from which human researchers selected five for further study. Three of these showed promise in preliminary studies on cells grown in the lab.
FutureHouse, a non-profit AI research lab in San Francisco,
California, developed the second system, called Robin, and instructed it to find drugs to treat an eye condition called dry age-related macular degeneration2. “}}

Gottweis, J. et al. Nature https://doi.org/10.1038/s41586-026-10644-y (2026).

Ghareeb, A. E. et al. Nature https://doi.org/10.1038/s41586-026-10652-y (2026).

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FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis | FDA

May 28, 2026

https://www.fda.gov/drugs/drug-safety-communications/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug QT:{{” We continue to receive reports of mental health side effects reported with montelukast use. Consistent with our prior evaluations, a wide variety of mental health side effects have been reported, including completed suicides. Some occurred during montelukast treatment and resolved after stopping the medicine. Other reports indicated that mental health side effects developed or continued after stopping montelukast. The Sentinel study, which studied asthma patients 6 years and older, and other observational studies did not find an increased risk of mental health side effects with montelukast compared to inhaled corticosteroids (ICS). However, the Sentinel study and the observational studies had some limitations which may affect how we interpret the results. We also reviewed animal studies, which showed that montelukast given orally reaches the brain in rats.1 (See Data Summary for more information) “}}

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Diphenhydramine-induced toxic psychosis – PubMed

May 28, 2026

https://pubmed.ncbi.nlm.nih.gov/3718632/
QT:{{” A 24-year-old man presented to the emergency department with acute anticholinergic symptoms, hallucinations, and bizarre behavior following a large ingestion of diphenhydramine (Benadryl). “}}

benadryl can cross BBB & cause delusions

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NYTimes: 6 Common Medications That May Lower Your Dementia Risk

May 3, 2026

the opposite of bad side effects – “side benefits.”
https://www.nytimes.com/2026/04/17/well/mind/medications-dementia-risk-decrease.html?smid=nytcore-ios-share

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4 Drugs That May Increase Your Dementia Risk

April 28, 2026

QT:{{”
Antihistamines
The class of medications with perhaps the most evidence of raising dementia risk are called anticholinergics. ….
“That once-in-a-while use of Benadryl is unlikely to increase risk for dementia,” Dr. Gray said. …
So-called second generation antihistamines, like Claritin and Zyrtec, don’t have anticholinergic activity, so they can be a safer option for seasonal allergies,

Antipsychotic Drugs
With mental health medications and dementia, there is a chicken-or-egg question: Do the drugs themselves increase the risk of dementia, or is it the conditions the drugs are prescribed for, such as depression or psychosis, that increase it? ….

Benzodiazepines
These mental health medications, which work on a specific
neurotransmitter to suppress brain activity, have also been linked to dementia…..

Proton Pump Inhibitors
Conflicting evidence has also been reported about proton pump inhibitors, which are often used to treat acid reflux. … Some proton pump inhibitors, like Prilosec, are purchased over the counter, so their use can be more difficult to track and analyze than prescription medications.
“}}

The New York Times
https://www.nytimes.com/2026/04/22/well/mind/medications-dementia-risk-increase.html

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Zebrafish reveal new insights into the biology of autism | Yale News

April 20, 2026

https://news.yale.edu/2026/04/02/zebrafish-reveal-new-insights-biology-autism?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Faculty_4-7-2026 QT{{” Here, we leverage the strengths of zebrafish as a scalable in vivo system to screen 520 US FDA-approved drugs and establish a database of their effects on sensory processing and arousal behaviors. Using this database, we nominate pharmacological candidates relevant to specific ASD genes or gene subgroups. “}}

Jamadagni, P., Dai, Y., Liu, Y., Mendes, H. W., Pruitt, A., Khan, S., Yang, L., Huang, T., Huang, X., Deans, P. J. M., Balafkan, N., Zhao, D., Xu, G., Liu, Y., Li, N., Wu, W., Fitzpatrick, S. E., Neelakantan, U., Chen, T., . . . Hoffman, E. J. (2026). Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish. Proceedings of the National Academy of Sciences, 123(12), e2518846123. https://doi.org/10.1073/pnas.2518846123

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Advancing precision health discovery in a genetically diverse health system: Cell

April 9, 2026

https://www.cell.com/cell/fulltext/S0092-8674(26)00274-6

Haas, R., Margolis, M. P., Wei, A., Yamaguchi, T. N., Feng, J., Tran, T., Tozzo, V., Queen, K. J., Mootor, M. F. E., Patil, V., Broudy, M. E., Tung, P., Alam, S., Martinez, D. B., Patel, Y., Caggiano, C., Zeltser, N., Hugh-White, R., Arbet, J., . . . Geschwind, D. H. (2026). Advancing precision health discovery in a genetically diverse health system. Cell. https://doi.org/10.1016/j.cell.2026.03.007

Epi dataset

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MCB111 Mathematics in Biology

February 22, 2026

http://mcb111.org/w06/w06-lecture.html
Has some nice textbook downloads – e.g.
http://mcb111.org/w06/KollerFriedman.pdf

QT:{{”
There are many good books to learn about probabilistic models. “Probabilistic graphical models: principles and techniques” (by Koller & Friedman) is a comprehensive source about more general probabilistic models than the one we are going to study here.
“}}
Subset of chap 7 focuses on GMRF

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