the opposite of bad side effects – “side benefits.”
https://www.nytimes.com/2026/04/17/well/mind/medications-dementia-risk-decrease.html?smid=nytcore-ios-share
Posts Tagged ‘drugtarget’
NYTimes: 6 Common Medications That May Lower Your Dementia Risk
May 3, 20264 Drugs That May Increase Your Dementia Risk
April 28, 2026QT:{{”
Antihistamines
The class of medications with perhaps the most evidence of raising dementia risk are called anticholinergics. ….
“That once-in-a-while use of Benadryl is unlikely to increase risk for dementia,” Dr. Gray said. …
So-called second generation antihistamines, like Claritin and Zyrtec, don’t have anticholinergic activity, so they can be a safer option for seasonal allergies,
Antipsychotic Drugs
With mental health medications and dementia, there is a chicken-or-egg question: Do the drugs themselves increase the risk of dementia, or is it the conditions the drugs are prescribed for, such as depression or psychosis, that increase it? ….
Benzodiazepines
These mental health medications, which work on a specific
neurotransmitter to suppress brain activity, have also been linked to dementia…..
Proton Pump Inhibitors
Conflicting evidence has also been reported about proton pump inhibitors, which are often used to treat acid reflux. … Some proton pump inhibitors, like Prilosec, are purchased over the counter, so their use can be more difficult to track and analyze than prescription medications.
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The New York Times
https://www.nytimes.com/2026/04/22/well/mind/medications-dementia-risk-increase.html
Zebrafish reveal new insights into the biology of autism | Yale News
April 20, 2026https://news.yale.edu/2026/04/02/zebrafish-reveal-new-insights-biology-autism?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Faculty_4-7-2026 QT{{” Here, we leverage the strengths of zebrafish as a scalable in vivo system to screen 520 US FDA-approved drugs and establish a database of their effects on sensory processing and arousal behaviors. Using this database, we nominate pharmacological candidates relevant to specific ASD genes or gene subgroups. “}}
Jamadagni, P., Dai, Y., Liu, Y., Mendes, H. W., Pruitt, A., Khan, S., Yang, L., Huang, T., Huang, X., Deans, P. J. M., Balafkan, N., Zhao, D., Xu, G., Liu, Y., Li, N., Wu, W., Fitzpatrick, S. E., Neelakantan, U., Chen, T., . . . Hoffman, E. J. (2026). Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish. Proceedings of the National Academy of Sciences, 123(12), e2518846123. https://doi.org/10.1073/pnas.2518846123
Advancing precision health discovery in a genetically diverse health system: Cell
April 9, 2026https://www.cell.com/cell/fulltext/S0092-8674(26)00274-6
Haas, R., Margolis, M. P., Wei, A., Yamaguchi, T. N., Feng, J., Tran, T., Tozzo, V., Queen, K. J., Mootor, M. F. E., Patil, V., Broudy, M. E., Tung, P., Alam, S., Martinez, D. B., Patel, Y., Caggiano, C., Zeltser, N., Hugh-White, R., Arbet, J., . . . Geschwind, D. H. (2026). Advancing precision health discovery in a genetically diverse health system. Cell. https://doi.org/10.1016/j.cell.2026.03.007
Epi dataset
MCB111 Mathematics in Biology
February 22, 2026http://mcb111.org/w06/w06-lecture.html
Has some nice textbook downloads – e.g.
http://mcb111.org/w06/KollerFriedman.pdf
QT:{{”
There are many good books to learn about probabilistic models. “Probabilistic graphical models: principles and techniques” (by Koller & Friedman) is a comprehensive source about more general probabilistic models than the one we are going to study here.
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Subset of chap 7 focuses on GMRF
linkstream2 microblog 