https://www.fda.gov/drugs/drug-safety-communications/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug QT:{{” We continue to receive reports of mental health side effects reported with montelukast use. Consistent with our prior evaluations, a wide variety of mental health side effects have been reported, including completed suicides. Some occurred during montelukast treatment and resolved after stopping the medicine. Other reports indicated that mental health side effects developed or continued after stopping montelukast. The Sentinel study, which studied asthma patients 6 years and older, and other observational studies did not find an increased risk of mental health side effects with montelukast compared to inhaled corticosteroids (ICS). However, the Sentinel study and the observational studies had some limitations which may affect how we interpret the results. We also reviewed animal studies, which showed that montelukast given orally reaches the brain in rats.1 (See Data Summary for more information) “}}
Posts Tagged ‘dc’
Diphenhydramine-induced toxic psychosis – PubMed
May 28, 2026https://pubmed.ncbi.nlm.nih.gov/3718632/
QT:{{” A 24-year-old man presented to the emergency department with acute anticholinergic symptoms, hallucinations, and bizarre behavior following a large ingestion of diphenhydramine (Benadryl). “}}
benadryl can cross BBB & cause delusions
Slow Is Smooth And Smooth Is Fast: Navy… | US Military
February 17, 2024Eisenhower’s Urgent/Important Principle/Matrix
July 11, 2022Legos, text blocks, TFs+motifs, & animations
March 7, 2021Slicker and newer release of “powers of 10” type of video [zooms into flower instead of a person though]:
https://www.youtube.com/watch?v=yvpPHoHh420
The first ~half of this video may be useful:
https://www.youtube.com/watch?v=D2cfP49KOno
Doesn’t include person/organ level, but still a nice demonstration — Structure of a chromosome and zoom in to DNA:
https://www.youtube.com/watch?v=57Q5V0HcIWU
May be useful in the context of basic brain biol:
https://www.youtube.com/watch?v=Zj3RxtJ_Ljc
Legos, text blocks, TFs+motifs, & animations
February 14, 2021DNA replication (addition of a single nucleotide): https://gifer.com/en/E43I
Dna Replication: https://www.pinterest.com/pin/372461831679047587/
Another for DNA replication: https://www.kozanbilgi.net/dna-yapisi.html
multigif of lac repressor binding to DNA:
https://proteopedia.org/wiki/index.php/Lac_repressor
gif of double-helix: https://gifer.com/en/Oun6
multigif of Lysine 18 sits in the major groove of DNA, recognizing the DNA sequence CGG:
https://www.umass.edu/molvis/workshop/imgs/polyview.htm
SK found this during our call — How to make your own DNA model using LEGO: https://www.youtube.com/watch?app=desktop&v=XV-k00iQk2w
50-second video on organization of the genome & base pairing (by NHGRI): https://www.youtube.com/watch?v=egVws2sZdd0
6-minute video on the structure of DNA:
https://www.youtube.com/watch?v=o_-6JXLYS-k
Misc sources:
https://www.uniprot.org/
http://jaspar.genereg.net/search?page=2&q=&tax_group=vertebrates&collection=CORE&page_size=250
covid-19 vaccine?
April 28, 2020In Race for a Coronavirus Vaccine, an Oxford Group Leaps Ahead
https://www.nytimes.com/2020/04/27/world/europe/coronavirus-vaccine-update-oxford.html
Compelling argument against Slack
May 27, 2019Stop Letting Modern Distractions Steal Your Attention
Making yourself inaccessible from time to time is essential to boosting your focus.
QT:{{”
This kind of task switching comes with a cost. It’s called attention residue, a term established by Sophie Leroy, a professor at the Bothell School of Business at the University of Washington. In a 2009 study, Dr. Leroy found that if people transition their attention away from an unfinished task, their subsequent task performance will suffer. For example, if you interrupt writing an email to reply to a text message, it will take time to refocus when you turn your attention back to finishing your email. That little bit of time of adjusting your focus — the residue — compounds throughout the day. As we fragment our attention, fatigue and stress increases, which negatively affects performance.
…
At the very least, she said, start leaving your phone behind during certain periods of the day, and perhaps establishing no-phone zones in your house or workplace. Treat it as an experiment: Try things and see what makes you feel good, she said.
“}}
A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies
January 6, 2018A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in #eQTL Studies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000770 Early discussion & development of PEER factors
linkstream2 microblog 