https://pubmed.ncbi.nlm.nih.gov/25624494/
QT:{{” Using a biophysical and evolutionary model, we show how these protein traits can emerge as evolutionary “spandrels” even if they do not confer an intrinsic fitness advantage. In particular, proteins can evolve strong binding interactions that have no functional role but merely serve to stabilize the protein if its misfolding is
deleterious. Furthermore, such proteins may have divergent fates, evolving to bind or not bind their targets depending on random mutational events. These observations may explain the abundance of apparently nonfunctional interactions among proteins observed in high-throughput assays “}}
Archive for the '–' Category
Protein folding and binding can emerge as evolutionary spandrels through structural coupling – PubMed
December 26, 2025do IDRs in protein tend to be multifunctional – Google Search
December 26, 2025https://www.google.com/search?q=do+IDRs+in+protein+tend+to+be+multifunctional&rlz=1C5CHFA_enUS1047US1048&oq=do+IDRs+in+protein+tend+to+be+multifunctional&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigATIHCAMQIRigATIHCAQQIRiPAtIBCjExMTAyMWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8 QT:{{” Yes, Intrinsically Disordered Regions (IDRs) in proteins are indeed highly multifunctional, acting as flexible hubs that bind diverse partners, integrate signals, and facilitate complex assembly, offering unique advantages over structured proteins through
context-dependent interactions and phase separation. Their flexibility allows them to adopt multiple conformations (a dynamic ensemble), enabling a single IDR to perform various roles like scaffolding, allosteric regulation, and participation in cellular condensates (LLPS). “}}
the discover of refactoring code in 1990s – Google Search
December 26, 2025https://www.google.com/search?q=the+discover+of+refactoring+code+in+1990s&rlz=1C5CHFA_enUS1047US1048&oq=the+discover+of+refactoring+code+in+1990s&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIJCAEQIRgKGKABMgkIAhAhGAoYoAEyCQgDECEYChigATIJCAQQIRgKGKABMgkIBRAhGAoYoAHSAQkxMDIzMWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8 QT:{{” Refactoring code wasn’t “discovered” in the 1990s but was formally defined and popularized then, with Bill Opdyke and Ralph Johnson coining the term in 1990 and Opdyke’s 1992 dissertation detailing it for OO systems; later, Martin Fowler’s 1999 book, Refactoring, solidified the practice, linking it with Extreme Programming (XP) and automated tools for cleaner, more maintainable code. “}}
technical debt related to code refactoring – Google Search
December 26, 2025https://www.google.com/search?q=technical+debt+related+to+code+refactoring&rlz=1C5CHFA_enUS1047US1048&oq=technical+debt+related+to+code+refactoring&gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCTEwNTcxajBqN6gCALACAA&sourceid=chrome&ie=UTF-8
QT:{{”
Technical debt related to code refactoring involves the extra work and slowdowns from taking shortcuts (like quick fixes or outdated designs) for faster delivery, with refactoring being the process of paying back this “debt” by restructuring code without changing behavior to improve quality, maintainability, and speed, often scheduled as a percentage of sprint time or addressed strategically when debt becomes
unmanageable
“}}
can a mouse be dropped 1000 feet without dying – Google Search
December 26, 2025QT:{{”
Yes, a mouse can likely survive a 1000-foot fall because its small size and low mass give it a low terminal velocity, meaning it doesn’t fall fast enough to be fatally injured, much like other tiny creatures; the air resistance is relatively high compared to its weight, allowing it to hit the ground with a gentle thud rather than a hard impact, though landing on a soft surface helps.
“”}}
What is Cooking by Ferran Adrià and elBullifoundation
December 23, 2025Beyond the Nobel Prizes Is a World of Scientific Awards
December 23, 2025Beyond the Nobel Prizes Is a World of Scientific Awards – The New York Times https://www.nytimes.com/2025/10/05/science/awards-prizes-non-nobels.html
Fellows | Benjamin Franklin College
December 23, 2025Landing | Five Acres in New York, NY
December 23, 2025Source: Five Acres | American restaurant in New York, NY
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