Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)
Archive for the 'SciLit' Category
The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
June 29, 2018Genomic insights into the origin of farming in the ancient Near East
June 28, 2018https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003663/
I. Lazaridis et al., “Genomic Insights into the Origin of Farming in the Ancient Near East,” Nature 536 (2016): 419–24
Genome-wide association study identifies 74 loci associated with educational attainment | Nature
June 28, 2018https://www.nature.com/articles/nature17671
Genome-wide association study identifies 74 loci associated with educational attainment
Aysu Okbay
, Jonathan P. Beauchamp
[…]
Daniel J. Benjamin
Nature 533, pages 539–542 (26 May 2016)
Ancient Admixture in Human History
June 28, 2018Admixture, Population Structure, and F-Statistics
June 28, 2018Genetics. 2016 Apr; 202(4): 1485–1501.
Published online 2016 Feb 4. doi: 10.1534/genetics.115.183913 PMCID: PMC4905545
PMID: 26857625
Admixture, Population Structure, and F-Statistics
Benjamin M. Peter1
The Genetic Legacy of the Mongols
June 28, 2018Am J Hum Genet. 2003 Mar; 72(3): 717–721.
Published online 2003 Jan 17. doi: 10.1086/367774
PMCID: PMC1180246
PMID: 12592608
The Genetic Legacy of the Mongols
Tatiana Zerjal,1 Yali Xue,1,2 Giorgio Bertorelle,3 R. Spencer Wells,4 Weidong Bao,1,5 Suling Zhu,1,5 Raheel Qamar,1,6Qasim Ayub,1,6 Aisha Mohyuddin,1,6 Songbin Fu,2 Pu Li,2 Nadira Yuldasheva,4,7 Ruslan Ruzibakiev,7 Jiujin Xu,5Qunfang Shu,5 Ruofu Du,5 Huanming Yang,5 Matthew E. Hurles,8 Elizabeth Robinson,1,* Tudevdagva
Gerelsaikhan,1,†Bumbein Dashnyam,9 S. Qasim Mehdi,5 and Chris Tyler-Smith1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180246/
T. Zerjal et al., “The Genetic Legacy of the Mongols,” American Journal of Human Genetics 72 (2003): 717–21.
How reliable are empirical genomic scans for selective sweeps?
June 20, 2018https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473181/
QT:{{”
One implication of these results is that, insofar as attributes of the beneficial mutation (e.g., the dominance coefficient) affect the power to detect targets of selection, genomic scans will yield an
unrepresentative subset of loci that contribute to adaptations. “}}
How reliable are empirical genomic scans for selective sweeps? Kosuke M. Teshima,1 Graham Coop, and Molly Przeworski1
Genome Res. 2006 Jun; 16(6): 702–712.
doi: 10.1101/gr.5105206
PMCID: PMC1473181
PMID: 16687733
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data
June 15, 2018Commentary
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data Carolyn Hutter + Jean Claude Zenklusen
https://www.sciencedirect.com/science/article/pii/S009286741830374X
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