Archive for the 'SciLit' Category
BMC Bioinformatics | Full text | QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments
November 1, 2015LoRDEC: accurate and efficient long read error correction
October 27, 2015proovread: large-scale high accuracy PacBio correction through iterative short read consensus
October 27, 2015analogies between josephson junction linkage and huygens coupled pendulums
October 24, 2015QT:{{”
In 1665, Christiaan Huygens [Huygens, 1673] noted “When we suspended two clocks so constructed from two hooks imbedded in the same wooden beam, the motions of each pendulum on opposite swings were so much in agreement that they never receded the least bit from each other and the sound of each was always heard simultaneously. Further, if this agreement was disturbed by some interference, it reestablished itself in a short time. For a long time I was amazed at this unexpected result, but after a careful examination finally found that the cause of this is due to the motion of the beam, even though this is hardly perceptible. The cause is that the oscillations of the pendula, in proportion to their weight, communicate some motion to the clocks. This motion, impressed onto the beam, necessarily has the effect of making the pendula come to a state of exactly contrary swings if it happened that they moved otherwise at first, and from this finally the motion of the beam completely ceases.” The study of coupled
oscillators has since become an active branch of mathematics, with applications in physics, biology, and chemistry. In physics, one encounters coupled oscillators in arrays of Josephson junctions [Chung et al., 1989, Blackburn et al., 1994], in modelling molecules [Sage, 1994], and in coupled lasers [Dente et al., 1990]. Coupled oscillators are also prevalent in biological systems. Most organisms appear to be coupled to various periodicities extant in our surroundings, such as the rotation of the earth about the sun, the alternation of night and day, or the tides. Not only do organisms exhibit periodicities due to their environment, but they also exhibit innate periodic behavior. Breathing, pumping blood, chewing, and galloping are examples of rhythmic patterns of motion…
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Huygens’s Clocks Revisited » American Scientist
October 24, 2015Single-cell ChIP-seq
October 23, 2015#Singlecell ChIPseq reveals…subpopulations defined by chromatin statehttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html Sparse data: on order of 1K uniq. reads/cell
http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html
Human Genome Project: Twenty-five years of big biology
October 17, 2015HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible
QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.
…
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Research profiles: A tag of one’s own : Naturejobs
October 10, 2015A tag of one’s own
http://www.nature.com/naturejobs/science/articles/10.1038/nj7572-281aMakes a convincing case for signing up for an ORCHID identifier & linking it to your papers
Panorama of ancient metazoan macromolecular complexes : Nature : Nature Publishing Group
September 26, 2015Panorama of ancient metazoan #macromolecular complexes
http://www.nature.com/nature/journal/v525/n7569/abs/nature14877.html Finding many more #complexes from integrating many co-elutions
http://www.nature.com/nature/journal/v525/n7569/full/nature14877.html#affil-auth
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