Are Isle Royale’s Wolves Chasing Extinction? Maybe from
#globalwarming; now population of ~10 wolves & ~1000 moose
http://www.sciencemag.org/content/340/6135/919.summary
Archive for the 'SciLit' Category
Are Isle Royale’s Wolves Chasing Extinction?
December 6, 2013Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
December 6, 2013Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
L Ward & M Kellis
http://www.sciencemag.org/content/337/6102/1675.abs
In general we know that conservation across species and within humans are correlated. In this paper the authors focus on emphasize the exceptions to this trend. They show that although only ~5% of the human genome is conserved across mammals, regulatory regions in an additional 4% of the genomes are conserved amongst humans. They also show that some elements are conserved across mammals but lack functional activity from ENCODE data and also do not show purifying selection amongst humans. The authors pinpoint regulatory regions near color vision and nerve-growth genes for that show human-specific constraint. This has been criticized in various publications since there are other genes that are higher up in the authors’ list but harder to explain for lineage-specific constraint.
Differential relationship of DNA replication timing to different forms of human mutation and variation.
December 6, 2013http://www.ncbi.nlm.nih.gov/pubmed/23176822
Am J Hum Genet. 2012 Dec 7;91(6):1033-40. doi:
10.1016/j.ajhg.2012.10.018. Epub 2012 Nov 21.
Differential relationship of DNA replication timing to different forms of human mutation and variation.
Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA.
Following the Flavor
December 6, 2013Great tidbits on how olives & wine seem less sour together than individually
Following the Flavor. Great tidbits on retronasal olfaction & how combos #taste different together than individually
http://www.sciencemag.org/content/340/6134/808.summary
Impact of Shale Gas Development on Regional Water Quality
December 6, 2013http://www.sciencemag.org/content/340/6134/1235009.abstract
Impact of Shale #Gas Development on Regional Water Quality: Disposal of #fracking wastewater will be a future issue
http://www.sciencemag.org/content/340/6134/1235009.abstract
1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
December 1, 2013Cell – Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate
November 30, 2013Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral #Cortex: less in mice gives more human-like folds
http://www.cell.com/retrieve/pii/S0092867413003498
And a Glossary of Their Quarry
November 29, 2013Glossary of Their Quarry. #exoplanet types: circumbinary, pulsar, core & rogue. Hot Jupiters, waterworlds, #exomoons
http://www.sciencemag.org/content/340/6132/570.summary
And a Glossary of Their Quarry.
Quoting from the podcast summary…
QT:{{”
So far, scientists have uncovered over 800 exoplanets roaming the cosmos—but as Sara Seager said earlier, we’re still searching for that Earth-like, Goldilocks planet.
…
Most of the planets we’ve discovered up until this point are what’s called Hot
Jupiters, which are gas giants about the size of Jupiter in our solar system with a pretty
big range on either side, so the smallest Hot Jupiters would be about 50 Earth masses.
…
The nastiest place to live would probably be pulsar planets.
…
And I
think another really unpleasant place to be would be a core planet. So core planets, they
sort of resemble something like Mercury, the size of Mercury, maybe even smaller.
…
I think just like in the solar system, actually, some of the best places for potentially
finding life outside of our solar system might be moons. So we call them exomoons or
moons orbiting exoplanets.
…
But we have seen and are seeing more and more of are theses
circumbinary planets,
which means a planet with two suns. So, Tatooine is sort of the iconic example.
…
Yes, waterworlds. So those are pretty diverse, and they are usually super-Earth-size so
they’ll be like 10 times the mass of Earth.
…
And then there are some planets that just go rogue.
“}}
A list of highly influential biomedical researchers, 1996–2011 – Boyack – 2013 – European Journal of Clin ical Investigation – Wiley Online Library
November 27, 2013http://onlinelibrary.wiley.com/doi/10.1111/eci.12171/full
~15M authors => ~150K w/ H>=20 => ~500 w/ highest citations &/or H >75 => 407 w/ further filters => 13 in Genomics & 4 from Yale
Genetic errors identified in 12 major cancer types
November 27, 2013Mutational landscape and significance across 12 major #cancer types: Common genes mutated in different cancers
http://www.nature.com/nature/journal/v502/n7471/full/nature12634.html
http://www.sciencedaily.com/releases/2013/10/131016132143.htm
Mutational landscape and significance across 12 major cancer types http://www.nature.com/nature/journal/v502/n7471/full/nature12634.html
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