Archive for the 'x78qt' Category

Media query (Nature Medicine): Quantum computing and health

January 19, 2025

Guenot, M. (2025). Can quantum computing crack the biggest challenges in health? Nature Medicine. https://doi.org/10.1038/s41591-024-03369-w

Great story by @Marianne_Guenot, providing good & *not* good news about QC for biomedicine.

QT:{{

The potential power of quantum computers in cracking problems that classical computers cannot is not all good news, says Mark Gerstein, a professor of biomedical informatics at Yale University who recently co-authored a review about quantum computing and health for Nature Methods3.

Experts predict that quantum computers could become fiendishly good at breaking through current encryption algorithms, says Gerstein, which could pose a problem for the privacy of confidential patient data. “There’s a huge push right now to get post-quantum cryptography to work,” he says.

The idea, then, is not for quantum computers to replace classical computers, says Gerstein. Instead, they should be considered as adding a node to a computing chain, as each can contribute different strengths to solve a problem. “The art here is figuring out which bit of this big calculation you can quantize,” says Gerstein.
“}}

AI tool that predicts gene activity could open path for disease treatments – The Washington Post

January 18, 2025

https://www.washingtonpost.com/science/2025/01/09/ai-predicts-gene-activity/

Johnson, M. (2025, January 8). Scientists trained AI to predict gene activity, a potentially powerful tool. Washington Post.
https://www.washingtonpost.com/science/2025/01/09/ai-predicts-gene-activity/

QT:{{”
Mark Gerstein, a professor of biomedical informatics at Yale School of Medicine, who was not involved in the new study, said that for 15 to 20 years experts have been systematically trying to make predictions about gene regulation, building on a trove of carefully made datasets. The data examined all genes in specific types of human cells ― for example, retinal cells or neurons ― measuring, among other things, gene expression and the binding of key proteins called transcription factors.
“This is a field poised to have this type of advancement by AI,” Gerstein said. “}}

Turning on pseudogenes | Interviews | Naked Scientists

January 3, 2025

QT:{{”
Kat – Do you think that there are other pseudogenes lurking the genome that have this kind of roles that are actually not drunk and not dead, and could be very active and important?

Howard – Yes, indeed. So, I think over the last several years, the other investigators have found have resembled from the ENCODE project that many pseudogenes are actually being transcribed, that they’re made. They’re evidence of their activation and that work was led by a Professor Mark Gerstein from Yale. More recently, other people have realised that pseudogenes because they’re copies of normal genes, they have many of the same regulatory sequences embedded in them. And so, when the pseudogenes are made, because of these regulatory sequences, compete for different cellular factors.
“}}

https://www.thenakedscientists.com/articles/interviews/turning-pseudogenes

Healthy lifestyle could counteract effects of life-shortening genes – UPI.com

November 16, 2024

https://www.upi.com/Health_News/2024/04/29/long-life-bad-genes/3351714421196/

QT:{{”
However, “it is quite notable that the four highlighted lifestyle factors did not include alcohol consumption, which one might have expected to be among the top factors,” said Mark Gerstein, a professor of biomedical informatics and data science at Yale School of Medicine in New Haven, Conn.

Gerstein nonetheless highlighted “the immense value of the UK Biobank, a resource assembled by the British government. This paper heavily relies on this primary data resource, which stands as a major testament to its significance.”
“}}

‘Anonymous’ genetic databases vulnerable to privacy leaks

October 26, 2024

https://www.nature.com/articles/d41586-024-03236-1

Yale Professors Awarded $1.9 Million Grant for Gene Expression Research < Yale School of Medicine

October 10, 2024

https://medicine.yale.edu/news-article/yale-professors-awarded-dollar19-million-grant-for-gene-expression-research/

NYTimes.com: As 23andMe Struggles, Concerns Surface About Its Genetic Data

October 6, 2024

As 23andMe Struggles, Concerns Surface About Its Genetic Data

A plummet in the company’s valuation and a recent board resignation have raised questions about the future of genetic data collected from millions of customers.

https://www.nytimes.com/2024/10/05/business/23andme-dna-bankrupt.html?smid=em-share

QT:{{”
“People don’t, I think, appreciate how large the genetic information for a person is,” Mark Gerstein, a professor of biomedical informatics at Yale University, said on Saturday.
“In theory, if there’s a mess-up with your credit card or Social Security number, you get a new one, it can be fixed,” Professor Gerstein said. “But there’s absolutely no way to get a new genome.” …
Looking at a genome can reveal a complicated structure, akin to ones and zeros of binary code, Professor Gerstein said. That might make it seem like the information is harder to glean than from a personal tech device.
“Superficially, there might be a comforting aspect to that, as opposed to if I peek in your email box,” he said. However complex the genome is, though, it can still hold sensitive private data.
“In the longer term, maybe it actually is more revealing,” he said. “}}

Yale Daily News Reporting on YDCoE…

September 26, 2024

https://yaledailynews.com/blog/2024/09/25/new-yale-medical-center-advances-rare-disease-diagnosing/

New Yale Medical Center advances rare disease diagnosing
Doctors at the new Yale Diagnostic Center of Excellence seek methods to diagnose and treat rare diseases.

DAVIS ZONG 11:49 PM, SEP 25, 2024

LLMs predict protein phases | Nature Methods

September 10, 2024

https://www.nature.com/articles/s41592-024-02421-4

Singh, A. (2024). LLMs predict protein phases. Nature.
https://doi.org/10.1038/s41592-024-02421-4

Yale Study Finds Potential in Predicting Immunotherapy Outcomes in Patients with Melanoma < Pathology

September 1, 2024

https://medicine.yale.edu/pathology/news-article/yale-study-finds-potential-in-predicting-immunotherapy-outcomes-in-patients-with-melanoma/