Archive for the 'x78qt' Category
Digital secrets of successful lab management
June 28, 2021‘Sanitizing’ functional genomics data may prevent privacy breaches | Spectrum | Autism Research News
January 16, 2021QT:{{”
The new data ‘sanitization’ technique obscures regions of a
participant’s genome in a dataset to secure her privacy, and may encourage more people to participate in genetic studies, says lead investigator Mark Gerstein, professor of biomedical informatics at Yale University.
“If someone hacks into your email, you can get a new email address; or if someone hacks your credit card, you can get a new credit card,” Gerstein says. “If someone hacks your genome, you can’t get a new one.”
To determine which information and how much of it should remain private to prevent a linkage attack, Gerstein and his colleagues performed linkage attacks on existing genetic datasets. In one sample attack, they compared two publicly available databases and RNA sequencing results to successfully identify 421 individuals.
In another linkage attack, Gerstein’s team sequenced the RNA of two volunteers and shuffled these data into a larger dataset. They then obtained DNA samples from the volunteers’ used coffee cups and sequenced their genomes. Again, they could link the two individuals to their genomes with a high degree of certainty.
Based on what they learned from the mock linkage attacks, Gerstein’s team developed a technique to mask some variants from a person’s genetic data while preserving where those variants are located in the genome. To do this, they replace the genetic variant of concern with one from a reference genome; which variants are removed depend on the genetic conditions or predispositions someone’s genetic data reveals.
Introducing too many of these privacy-masking variants can decrease the usefulness of the data. But Gerstein’s team struck a balance that enables researchers to obtain data on gene-expression values but also enables study participants to dictate how much of their genetic information they wish to keep hidden.
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https://www.spectrumnews.org/news/sanitizing-functional-genomics-data-may-prevent-privacy-breaches/
BBC Media Request = Data Sanitisation
December 22, 2020The Naked Scientists
Data sanitisation tool plugs privacy gap
Functional genomics data is vulnerable to de-anonymising attacks… 17 December 2020
Interview with
Mark Gerstein, Yale University
Part of the show RNA Vaccines, Privacy, and Penguins
part of the Naked Genetics podcast, on all podcast platforms and o
site here: https://www.thenakedscientists.com/podcasts/naked-genetics/rna-vaccines-privacy-and-penguins
direct link: https://www.thenakedscientists.com/articles/interviews/data-sanitisation-tool-plugs-privacy-gap
Researchers Use AI to Predict the Frequencies of Drug Side Effects
September 20, 2020Massive encyclopedia catalogs genome’s regulatory regions | Spectrum | Autism Research News
August 26, 2020$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger < Yale School of Medicine
August 9, 2020Scientists find ‘drivers’ of cancer, but warn: Don’t ignore ‘passengers’ | YaleNews
February 23, 2020Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations | GenomeWeb
February 23, 2020Pan-Cancer Analysis Points to Possible Functional Effects of Passenger Mutations _ GenomeWeb.pdf
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