https://www.nytimes.com/2025/09/24/health/maria-branyas-longevity-genes-microbiome.html
Posts Tagged ‘aging’
How Did Maria Branyas Morera, Who Was the World’s Oldest Person, Live So Long? – The New York Times
September 27, 2025Do longevity drugs work?
August 15, 2025A Common Assumption About Aging May Be Wrong, Study Suggests – The New York Times
July 6, 2025https://www.nytimes.com/2025/06/30/well/live/aging-inflammation-lifespan-environment.html
A Common Assumption About Aging May Be Wrong, Study Suggests
Experts have long pointed to inflammation as a natural part of getting older. But a new paper suggests it might be more a product of our environment.
June 30, 2025
The Abstract: 8 Compounds That Target Aging
March 18, 2025Guarente, L., Sinclair, D. A., & Kroemer, G. (2024). Human trials exploring anti-aging medicines. Cell Metabolism, 36(2), 354–376. https://doi.org/10.1016/j.cmet.2023.12.007
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00458-8
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In a recent issue of Cell Metabolism, Guarente co-authored a review article about human trials exploring compounds that target pathways and mechanisms of aging along with David Sinclair, Ph.D., one of Dr. Guarente’s postdoctoral mentees and now a professor of genetics at Harvard Medical School, and Guido Kroemer, M.D., Ph.D., a professor at the Université Paris Cité. Guarente and his colleagues focus on eight drugs and compounds: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories.
These interventions made the list for four reasons: 1) they’re well-represented in ongoing or completed human clinical trials; 2) they’ve been shown to slow aging in preclinical studies; 3) they’re thought to be sufficiently safe for long-term use in humans; and 4) they work by targeting the hallmarks of aging.
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Gompertz–Makeham law of mortality – Wikipedia
January 30, 2025Gompertz–Makeham law of mortality – Wikipedia
December 31, 2024Is Biological Age Testing Accurate or Useful? – The New York Times
December 15, 2024Some claim human lifespans can be lengthened indefinitely
December 11, 2023https://www.economist.com/technology-quarterly/2023/09/25/some-claim-human-lifespans-can-be-lengthened-indefinitely
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There is a story about a blues musician who, when questioned on his 100th birthday about his decades of smoking and drinking, responded that if he’d known he was going to live so long, he’d have taken better care of himself. Bryan Johnson is that apocryphal bluesman’s polar opposite. He has been taking care of himself for years to a degree as remarkable, in its way, as the deepest devotion to bourbon and bad choices. …
The daily regime which he and his many doctors have devised makes life in Biosphere 2 look sybaritic. A kilogram of vegetables, all before 11am, rigorous workouts lasting 45-60 minutes, and 100 pills, including metformin and rapamycin. His vital functions are subjected to the sort of continuous scrutiny more usually associated with laboratory animals. He says he is ageing at 69% of the normal rate. Mr Johnson, who has been described as the most measured man in the world, can afford the team of medics, trainers and dieticians who minister to him because selling Braintree, an electronic-payments company which he founded, left him with a net worth of more than $100m. For mere mortals, however, a range of less intensive options are available.
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