Posts Tagged ‘Elysium’

Anti-ageing pill pushed as bona fide drug

July 4, 2017

QT:{{‘

“Current treatments for diseases related to ageing “just exchange one disease for another”, says physician Nir Barzilai of the Albert Einstein College of Medicine in New York. That is because people treated for one age-related disease often go on to die from another relatively soon thereafter. “What we want to show is that if we delay ageing, that’s the best way to delay disease.”

Barzilai and other researchers plan to test that notion in a clinical trial called Targeting Aging with Metformin, or TAME. They will give the drug metformin to thousands of people who already have one or two of three conditions — cancer, heart disease or cognitive impairment — or are at risk of them. People with type 2 diabetes cannot be enrolled because metformin is already used to treat that disease.
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http://www.nature.com/news/anti-ageing-pill-pushed-as-bona-fide-drug-1.17769

Can we hit the snooze button on aging? | March 6, 2017 Issue – Vol. 95 Issue 10 | Chemical & Engineering News

April 23, 2017

Can we hit the snooze button on #aging?
http://CEN.acs.org/articles/95/i10/hit-snooze-button-aging.html Various ways to tackle this timeless issue; for me more pertinent by the day

Silicon Valley’s Quest to Live Forever

April 10, 2017

SV’s Quest to Live Forever
http://www.NewYorker.com/magazine/2017/04/03/silicon-valleys-quest-to-live-forever Cal. restriction to #Singularity: Immortalists v Healthspanners, Meat Puppets v RoboCops

QT:{{”

“Immortalists fall into two camps. Those who might be called the Meat Puppets, led by de Grey, believe that we can retool our biology and remain in our bodies. The RoboCops, led by Kurzweil, believe that we’ll eventually merge with mechanical bodies and/or with the cloud. Kurzweil is a lifelong fixer and optimizer: early in his career, he invented the flatbed scanner and a machine that reads books aloud to the blind. Those inventions have improved dramatically in subsequent iterations, and now he’s positive that what he calls “the law of accelerating returns” for human longevity is about to kick in.”


“The battle between healthspanners and immortalists is essentially a contest between the power of evolution as ordained by nature and the potential power of evolution as directed by man. The healthspanners see us as subject to linear progress: animal studies take the time that they take; life sciences move at the speed of life. Noting that median life expectancy has been increasing in developed nations by about two and a half years a decade, Verdin told me, “If we can keep that pace up for the next two hundred years, and increase our life spans by forty years, that would be incredible.”

The immortalists have a different view of both our history and our potential. They see centuries of wild theorizing (that aging could be reversed by heating the body, or by breathing the same air as young virgins) swiftly replaced by computer-designed drugs and gene therapies. Bill Maris said, “Health technology, which for five thousand years was symptomatic and episodic—‘Here are some
leeches!’—is becoming an information technology, where we can read and edit our own genomes.”

Many immortalists view aging not as a biological process but as a physical one: entropy demolishing a machine. And, if it’s a machine, couldn’t it be like a computer?

“And yet. Last year, the geneticist Nir Barzilai hosted a screening of a documentary about longevity, and afterward he posed a question to the three hundred people in the audience. He told me, “I said, ‘In nature, longevity and reproduction are exchangeable. So Choice One is, you are immortalized, but there is no more reproduction on Earth, no pregnancy, no first birthday, no first love’—and I go on and on and on.” He laughed, amused by his own determination to load the dice. “ ‘Choice Two,’ I said, ‘is you live to be eighty-five and not one day sick, everything healthy and fine, and then one morning you just don’t wake up.” The vote was decisive, he said. “Choice One got ten or fifteen people. Everyone else raised their hands for Choice Two.”

This wish to preserve life as we know it, even at the cost of dying, is profoundly human. We are encoded”
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Dietary supplements: Nobel or ignoble – The Boston Globe

April 3, 2017

https://www.bostonglobe.com/opinion/2017/03/30/dietary-supplements-nobel-ignoble/e5E6Cklw3RxlExEtGJe6mL/amp.html

Pterostilbene – Scientific Review on Usage, Dosage, Side Effects | Examine.com

March 20, 2017

https://examine.com/supplements/pterostilbene/

QT:{{"
Low doses of pterostilbene (for a human, 10mg or less usually) seem to hold some benefit for cognition, and are thought to be one of the bioactive components of blueberries (alongside the anthocyanin content). Higher doses may not have said neurological effects, but higher supplemental dosages of pterostilbene (in the 250-500mg range usually) seem to have benefit for reducing cholesterol and glucose in research animals. The reduction in blood glucose and improvement in insulin sensitivity is quite potent, with a few studies noting that it is comparable to metformin as the reference drug.
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The Weird Business Behind a Trendy “Anti-Aging” Pill | WIRED

March 13, 2017

https://www.wired.com/2016/07/confused-elysiums-anti-aging-drug-yeah-fda/

Is Elysium Health’s Basis the Fountain of Youth? — Science of Us

March 11, 2017

http://nymag.com/scienceofus/2016/08/is-elysium-healths-basis-the-fountain-of-youth.html

Supplement Ratings and Reviews – Labdoor

April 9, 2016

https://labdoor.com/

Nice site w/ rankings of vitamins

Here’s the vit. D rankings:

01 Carlson Labs Vitamin D3 A
02 Nutrigold Vitamin D3 Gold 1000 IU A
03 Nutrigold Vitamin D3 Gold 2000 IU A
04 Nature Made Vitamin D3 A
05 Nature’s Way Vitamin D3 A
06 Nordic Naturals Vitamin D3 A
07 NOW Foods Vitamin D3 A
08 Solgar Vitamin D3 A
09 GNC Vitamin D3 A
10 Thorne Research Vitamin D A

Here’s the mulitvitamin rankings:

01 Garden of Life Vitamin Code For Men A
02 Garden of Life Vitamin Code Perfect Weight A
03 Nature’s Way Alive Max Potency Multivitamin A
04 Rainbow Light Men’s One A
05 Garden of Life Vitamin Code For Women A
06 NOW Foods Adam Men’s Multivitamin A
07 NOW Foods Eve Women’s Multivitamin A
08 GNC Mega Men A
09 Carlson Labs Super 2 Daily A
10 Rainbow Light Women’s One A
11 GNC Mega Men Energy & Metabolism A
12 Optimum Nutrition Opti-Men A
13 TwinLab Daily One Caps A
14 Garden of Life Vitamin Code Raw One For Men A-
15 Controlled Labs Orange TRIad A-

https://labdoor.com/rankings/multivitamins
Very critical of centrum!

Is the Secret to Longevity Available from this Website? | MIT Technology Review

June 16, 2015

Is the Secret to Longevity Available from this
Website?http://www.technologyreview.com/news/534636/the-anti-aging-pill NAD-replenishment pill w/ co-factor precursor + antioxidant

(NB: I’ve advised Elysium.)

QT:{{”

““NAD replacement is one of the most exciting things happening in the biology of aging,” says Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York, who has coauthored scientific papers with Guarente but is not involved in Elysium. “The frustration in our field is that we have shown we can target aging, but the FDA does not [recognize it] as an indication.”

Other experts said while NAD may decline with age, there is limited evidence that aging can be affected by restoring or increasing NAD levels. “There is enough evidence to be excited, but not completely compelling evidence,” said Brian K. Kennedy, CEO of the
California-based Buck Institute for Research on Aging.

Guarente says Elysium’s pill includes a precursor to NAD, called nicotinamide riboside, which the body can transform into NAD and put to use. In addition, the pill contains pterostilbene, an antioxidant that Guarente says stimulates sirtuins in a different way. Both ingredients can already be found in specialty vitamins. “We expect a synergistic effect [from] combining them,” he says.”

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