Posts Tagged ‘encodec’

Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies – ScienceDirect

April 28, 2018

Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly

ncdriver and ENCODE

March 17, 2018

Received: 13 November 2017 Revised: 22 November 2017 Accepted: 29 November 2017 https://www.nature.com/articles/s41525-017-0040-5.pdf

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma | Nature Genetics

February 11, 2018

https://www.nature.com/articles/ng.3861?WT.ec_id=NG-201706&spMailingID=54145295&spUserID=MTc2NTYxNjY4OQS2&spJobID=1164335784&spReportId=MTE2NDMzNTc4NAS2

Chromatin states define tumour-specific T cell dysfunction and reprogramming | Nature

November 19, 2017

https://www.nature.com/articles/nature22367

STAR Methods

September 28, 2017

Here is the STAR Methods format (Structured, Transparent, Accessible Reporting) introduced last year by Cell, marketed as a structure that “promotes transparent reporting of experimental design and
methodological details.” Details are in the links below.

Editorial: http://www.cell.com/cell/fulltext/S0092-8674(16)31072-8 Instructions: http://www.cell.com/star-authors-guide
Website: http://www.cell.com/star-methods

US cancer institute to overhaul tumour cell lines

July 9, 2017

QT:{{"
“The NCI will continue to supply the NCI-60 cell lines to researchers, but will eventually refocus its drug screening on newer models. It is developing hundreds of ‘patient-derived xenografts’ (PDXs), which are created by implanting small chunks of human tumours into mice. There, the tumours grow in an environment that, although not human, better mimics their native environment”
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