Posts Tagged ‘from_pe’

7 year-old Youtube star

December 5, 2018

https://www.theguardian.com/technology/shortcuts/2018/dec/04/meet-ryan-the-seven-year-old-youtuber-who-made-173m-in-a-year

Meet Ryan, the seven-year-old YouTuber who made £17.3m in a year | Technology | The Guardian
http://www.theguardian.com
Name: Ryan. Age: Seven. Value: £17.3m. It’s wrong to hate a child, isn’t it? Yes! Of course it is. Especially if you hate them for having more money than you. Let’s end this line of inquiry …

Potential role for microglia in Alzheimer’s

June 2, 2018

http://www.sciencemag.org/news/2016/03/alzheimer-s-may-be-caused-haywire-immune-system-eating-brain-connections

Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline

JClub papers

February 16, 2017

A #circadian gene-expr atlas in mammals by @jbhclock lab
http://www.PNAS.org/content/111/45/16219.abstract 43% of genes have a daily rhythm in at least 1 tissue [1/2]

.@jbhclock Fewest circadian genes in brain; most in liver. Perhaps this more reflects daily feeding cycle than true light-dark cycle? [2/2]

A circadian gene expression atlas in mammals: Implications for biology and medicine

Ray Zhanga,1,
Nicholas F. Lahensa,1,
Heather I. Ballancea,
Michael E. Hughesb,2, and
John B. Hogenescha,2

* Interestingly brain regions have the fewest circ genes(only ~3%), liver has most

* Diseases assoc with circadian genes correlate with NIH funding

* Genes can have up to a 6-hour phase diff. Between diff. organs (eg Vegfa betw. Heart & fat)

* 56 of the top 100 drugs incl. Top 7, targeted the product of a circadian gene. Related to the half-life of drugs.

* Could the liver genes be more reflective of feeding rhythm rather than true circadian clock.