Posts Tagged ‘pe’

Emperor Akihito’s publications

March 17, 2018 Some of the Publications by His Majesty Emperor Akihito
Some of the Publications by His Majesty Emperor Akihito The Emperor, then Crown Prince Akihito, co-authored the entry on gobiid fishes in the The Fishes of the

JClub papers

February 16, 2017

A #circadian gene-expr atlas in mammals by @jbhclock lab 43% of genes have a daily rhythm in at least 1 tissue [1/2]

.@jbhclock Fewest circadian genes in brain; most in liver. Perhaps this more reflects daily feeding cycle than true light-dark cycle? [2/2]

A circadian gene expression atlas in mammals: Implications for biology and medicine

Ray Zhanga,1,
Nicholas F. Lahensa,1,
Heather I. Ballancea,
Michael E. Hughesb,2, and
John B. Hogenescha,2

* Interestingly brain regions have the fewest circ genes(only ~3%), liver has most

* Diseases assoc with circadian genes correlate with NIH funding

* Genes can have up to a 6-hour phase diff. Between diff. organs (eg Vegfa betw. Heart & fat)

* 56 of the top 100 drugs incl. Top 7, targeted the product of a circadian gene. Related to the half-life of drugs.

* Could the liver genes be more reflective of feeding rhythm rather than true circadian clock.