Posts Tagged ‘pe’

Emperor Akihito’s publications

March 17, 2018

http://www.in.emb-japan.go.jp/PDF/(15)Some%20of%20the%20Publications%20by%20H.M.Emperor%20Akihito.pdf Some of the Publications by His Majesty Emperor Akihito
http://www.in.emb-japan.go.jp
Some of the Publications by His Majesty Emperor Akihito The Emperor, then Crown Prince Akihito, co-authored the entry on gobiid fishes in the The Fishes of the

JClub papers

February 16, 2017

A #circadian gene-expr atlas in mammals by @jbhclock lab
http://www.PNAS.org/content/111/45/16219.abstract 43% of genes have a daily rhythm in at least 1 tissue [1/2]

.@jbhclock Fewest circadian genes in brain; most in liver. Perhaps this more reflects daily feeding cycle than true light-dark cycle? [2/2]

A circadian gene expression atlas in mammals: Implications for biology and medicine

Ray Zhanga,1,
Nicholas F. Lahensa,1,
Heather I. Ballancea,
Michael E. Hughesb,2, and
John B. Hogenescha,2

* Interestingly brain regions have the fewest circ genes(only ~3%), liver has most

* Diseases assoc with circadian genes correlate with NIH funding

* Genes can have up to a 6-hour phase diff. Between diff. organs (eg Vegfa betw. Heart & fat)

* 56 of the top 100 drugs incl. Top 7, targeted the product of a circadian gene. Related to the half-life of drugs.

* Could the liver genes be more reflective of feeding rhythm rather than true circadian clock.