The #Height Gap – betw. individuals more rel. w. genes but betw. populations w. environment
http://www.NewYorker.com/magazine/2004/04/05/the-height-gap Why Americans are short!
Posts Tagged ‘genetics’
The Height Gap – The New Yorker
September 18, 2016Genetics And That Striped Dress
May 2, 2015Genetics & That Striped Dress
http://blog.23andme.com/23andme-research/genetics-and-that-striped-dress @23andme on-the-fly SNP associations w/ pop trends. Next: targeting ads w/ alleles
Identification of a large set of rare complete human knockouts : Nature Genetics : Nature Publishing Group
April 3, 2015A large set [1171] of rare complete human knockouts
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3243.html ~8% Icelanders have one; from a larger set of ~5K genes w/ #LOFs
Also:
In Iceland’s DNA, New Clues to Disease-Causing Genes – NYTimes.com
http://www.nytimes.com/2015/03/26/science/in-icelands-dna-clues-to-what-genes-may-cause-disease.html
by Carl Zimmer
QT:{{”
The Decode researchers looked for human knockouts in Iceland — and found a lot of them. Nearly 8 percent of Icelanders lack a working version of a gene. All told, the Decode team identified 1,171 genes shut down in Icelandic knockouts.
In a 2012 study, Dr. MacArthur and his colleagues were able to identify just 253 genes knocked out in humans.
“}}
Convergent transcriptional specializations in the brains of humans and song-learning birds
March 15, 2015Convergent…specializations in brains of humans & songbirds http://www.sciencemag.org/content/346/6215/1256846.long Both have matching expression patterns across regions
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
February 21, 2015Human & mouse [mRNA] #methylomes revealed by m6A-seq http://www.nature.com/nature/journal/v485/n7397/full/nature11112.html Conservation across species & conditions (for most sites)
Dan Dominissini,
Sharon Moshitch-Moshkovitz,
Schraga Schwartz,
…
Rotem Sorek
& Gideon Rechavi
Nature 485, 201–206 (10 May 2012) doi:10.1038/nature11112
High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
February 21, 2015High-res mapping reveals a conserved…mRNA methylation program http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956118/ Predicting methyl sites w/ seq., structure & position
Cell. 2013 Dec 5; 155(6): 1409–1421.
Published online 2013 Nov 21. doi: 10.1016/j.cell.2013.10.047 PMCID: PMC3956118
NIHMSID: NIHMS550466
High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
Schraga Schwartz,1,* Sudeep D. Agarwala,2,* Maxwell R. Mumbach,1 Marko Jovanovic,1 Philipp Mertins,1 Alexander Shishkin,1 Yuval Tabach,3,4 Tarjei S Mikkelsen,1 Rahul Satija,1 Gary Ruvkun,3,4 Steven A. Carr,1 Eric S. Lander,1,5,6 Gerald R. Fink,1,2,8 and Aviv Regev 1,7,8
Searching for missing heritability: Designing rare variant association studies
October 5, 2014Searching for missing heritability… rare variant association studies http://www.pnas.org/content/111/4/E455.abstract Pessimistic on #RVAS in #noncoding regions
Nice overview of study design. Good journal-club material.
‘A Troublesome Inheritance’ and ‘Inheritance’
August 10, 2014‘A Troublesome Inheritance’ and ‘Inheritance’
http://www.nytimes.com/2014/07/13/books/review/a-troublesome-inheritance-and-inheritance.html
http://www.amazon.com/Inheritance-Genes-Change-Lives—Lives/dp/1455549444
available via audible
QT:{{”
One can find more productive ways to think about genes. As a physician who researches and treats rare genetic disorders, Sharon Moalem, the author of “Inheritance,” sees firsthand how sharply DNA can constrain our lives. Yet “our genes aren’t as fixed and rigid as most of us have been led to believe,” he says, for while genetic defects often create havoc, variable gene expression (our genes’ capacity to respond to the environment with a flexibility only now being fully recognized) can give our bodies and minds surprising resilience. In his new book, Moalem describes riveting dramas emerging from both defective genes and reparative epigenetics.
“}}
Neutral genomic regions refine models of recent rapid human population growth
January 19, 2014Neutral genomic regions refine models of recent rapid human population growth
Elodie Gazave, Li Ma, Diana Chang, Alex Coventry, Feng Gao, Donna Muzny, Eric Boerwinkle, Richard A. Gibbs, Charles F. Sing, Andrew G. Clark, and Alon Keinan
QT:{{”
Recent rapid growth of human populations predicts that a large number of genetic variants in populations today are very rare, i.e., appear in a small number of individuals. This effect is similar to that of purifying selection, which drives deleterious alleles to become rarer. “}}
Malcolm Gladwell: Do Genetic Advantages Make Sports Unfair? : The New Yorker
September 3, 2013http://www.newyorker.com/arts/critics/atlarge/2013/09/09/130909crat_atlarge_gladwell
A CRITIC AT LARGE
MAN AND SUPERMAN
In athletic competitions, what qualifies as a sporting chance?
BY MALCOLM GLADWELL
Do #Genetic Advantages Make #Sports Unfair? In contrast to doping, corrective operations, &c http://nyr.kr/1ftwS9p MT @drbachinsky
linkstream2 microblog 