Posts Tagged ‘gpm0mg’

President Weighs In on Data From Genes

February 28, 2016

.@Potus Weighs In on…Genes from the top an opinion that you own your own DNA & researchers shouldn’t hoard data

Do You Know What the 10 Most Expensive Medicare Part B Drugs Are?

February 13, 2016


5. Erbitux
Treats: cancer
Cost: $25,898

4. Primacor, Primacor in Dextrose
Treats: acute decompensated heart failure
Cost: $62,790

3. Ventavis
Treats: pulmonary arterial hypertension
Cost: $84,205

2. Remodulin
Treats: pulmonary arterial hypertension
Cost: $130,772

1. Factor viii Recombinant (various)
Treats: hemophilia A
Cost: $216,833

contains broken link to GAO report –

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

February 12, 2016

Reprogramming…#epigenome & transcriptome in…muscle after training Delta(Me) from #exercise in 1 leg v. other

Exercise has long been known to have an effect on health, lowering the incidence of cardiovascular disease, obesity, and type 2 diabetes. Recently, it has been found that exercise can have a direct effect on DNA methylation and gene expression. A group of 23 subjects exercised one leg but not the other for 45 minutes four times a week for three months. At the end of this period, the methylation and gene expression patterns were different in the exercised leg relative to the one that did not exercise, indicating a direct effect of exercise on

Quote from:,+lowering+the+incidence+of+cardiovascular+disease,+obesity,+and+type+2+diabetes.+Recently,+it+has+been+found+that+exercise+can+have+a+direct+effect+on+DNA+methylation+and+gene+expression.+A+group+of+23+subjects+exercised+one+leg+but+not+the+other+for+45+minutes+four+times+a+week+for+three+months.+At+the+end+of+this+period,+the+methylation+and+gene+expression+patterns+were+different+in+the+exercised+leg+relative+to+the+one+that+did+not+exercise,+indicating+a+direct+effect+of+exercise+on+epigenetics.&source=bl&ots=paSuwD6wvw&sig=gwFDNYvSMRlkFouTcaoyf9q3c20&hl=en&sa=X&ved=0ahUKEwjZzv7imu3KAhXK5SYKHaP6DdEQ6AEIHjAA#v=onepage&q=Exercise%20has%20long%20been%20known%20to%20have%20an%20effect%20on%20health%2C%20lowering%20the%20incidence%20of%20cardiovascular%20disease%2C%20obesity%2C%20and%20type%202%20diabetes.%20Recently%2C%20it%20has%20been%20found%20that%20exercise%20can%20have%20a%20direct%20effect%20on%20DNA%20methylation%20and%20gene%20expression.%20A%20group%20of%2023%20subjects%20exercised%20one%20leg%20but%20not%20the%20other%20for%2045%20minutes%20four%20times%20a%20week%20for%20three%20months.%20At%20the%20end%20of%20this%20period%2C%20the%20methylation%20and%20gene%20expression%20patterns%20were%20different%20in%20the%20exercised%20leg%20relative%20to%20the%20one%20that%20did%20not%20exercise%2C%20indicating%20a%20direct%20effect%20of%20exercise%20on%20epigenetics.&f=false

NIH precision vs personalized medicine

February 12, 2016

There is a lot of overlap between the terms “precision medicine” and “personalized medicine.” According to the National Research Council, “personalized medicine” is an older term with a meaning similar to “precision medicine.” However, there was concern that the word “personalized” could be misinterpreted to imply that treatments and preventions are being developed uniquely for each individual; in precision medicine, the focus is on identifying which approaches will be effective for which patients based on genetic, environmental, and lifestyle factors. The Council therefore preferred the term “precision medicine” to “personalized medicine.”

The Aging Stress Response

February 12, 2016

Aging Pathways: insulin-foxo, mTOR, AMPK, Sirtuin

AMPK and Aging – Life Extension

February 12, 2016

mTOR is a key modulator of ageing and age-related disease

February 12, 2016

Dietary modification of the microbiome affects risk for cardiovascular disease. – PubMed – NCBI

February 10, 2016

Age-related macular degeneration – Genetics Home Reference

February 10, 2016

A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration

Zhenglin Yang1,2,3,*,
Nicola J. Camp4,*,
Hui Sun5,
Zongzhong Tong1,2,
Daniel Gibbs1,2,
D. Joshua Cameron1,2,
Haoyu Chen1,2,
Yu Zhao1,2,
Erik Pearson1,2,
Xi Li1,2,
Jeremy Chien6,
Andrew DeWan7,
Jennifer Harmon1,2,
Paul S. Bernstein1,
Viji Shridhar6,
Norman A. Zabriskie1,
Josephine Hoh7,
Kimberly Howes1,
Kang Zhang1,2,†

Age-related macular degeneration results in blindness, and one major locus (HTRAX) accounts for approximately one-half of genetic cases. “}}
Should be HTRA1

Genomics and Personalized Medicine: What Everyone Needs to Know(R): 9780190234775: Medicine & Health Science Books @

February 1, 2016