.@Potus Weighs In on…Genes
http://www.nytimes.com/2016/02/26/us/politics/president-obama-weighs-in-on-data-from-genes.html from the top an opinion that you own your own DNA & researchers shouldn’t hoard data
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President Weighs In on Data From Genes
February 28, 2016Do You Know What the 10 Most Expensive Medicare Part B Drugs Are?
February 13, 2016http://www.medicarearticles.com/do-you-know-what-the-10-most-expensive-medicare-part-b-drugs-are
QT:{{”
5. Erbitux
Treats: cancer
Cost: $25,898
4. Primacor, Primacor in Dextrose
Treats: acute decompensated heart failure
Cost: $62,790
3. Ventavis
Treats: pulmonary arterial hypertension
Cost: $84,205
2. Remodulin
Treats: pulmonary arterial hypertension
Cost: $130,772
1. Factor viii Recombinant (various)
Treats: hemophilia A
Cost: $216,833
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contains broken link to GAO report –
http://www.medicarenewsgroup.com/news/medicare-faqs/individual-faq?faqId=48ec6c39-e49a-4bb9-a892-19a6abac8237
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training
February 12, 2016Reprogramming…#epigenome & transcriptome in…muscle after training http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622000/ Delta(Me) from #exercise in 1 leg v. other
QT:{{”
Exercise has long been known to have an effect on health, lowering the incidence of cardiovascular disease, obesity, and type 2 diabetes. Recently, it has been found that exercise can have a direct effect on DNA methylation and gene expression. A group of 23 subjects exercised one leg but not the other for 45 minutes four times a week for three months. At the end of this period, the methylation and gene expression patterns were different in the exercised leg relative to the one that did not exercise, indicating a direct effect of exercise on
epigenetics.
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Quote from:
NIH precision vs personalized medicine
February 12, 2016QT:{{”
There is a lot of overlap between the terms “precision medicine” and “personalized medicine.” According to the National Research Council, “personalized medicine” is an older term with a meaning similar to “precision medicine.” However, there was concern that the word “personalized” could be misinterpreted to imply that treatments and preventions are being developed uniquely for each individual; in precision medicine, the focus is on identifying which approaches will be effective for which patients based on genetic, environmental, and lifestyle factors. The Council therefore preferred the term “precision medicine” to “personalized medicine.”
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http://ghr.nlm.nih.gov/handbook/precisionmedicine/precisionvspersonalized
The Aging Stress Response
February 12, 2016http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987618/
Aging Pathways: insulin-foxo, mTOR, AMPK, Sirtuin
AMPK and Aging – Life Extension
February 12, 2016mTOR is a key modulator of ageing and age-related disease
February 12, 2016Dietary modification of the microbiome affects risk for cardiovascular disease. – PubMed – NCBI
February 10, 2016Age-related macular degeneration – Genetics Home Reference
February 10, 2016A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang1,2,3,*,
Nicola J. Camp4,*,
Hui Sun5,
Zongzhong Tong1,2,
Daniel Gibbs1,2,
D. Joshua Cameron1,2,
Haoyu Chen1,2,
Yu Zhao1,2,
Erik Pearson1,2,
Xi Li1,2,
Jeremy Chien6,
Andrew DeWan7,
Jennifer Harmon1,2,
Paul S. Bernstein1,
Viji Shridhar6,
Norman A. Zabriskie1,
Josephine Hoh7,
Kimberly Howes1,
Kang Zhang1,2,†
http://science.sciencemag.org/content/314/5801/992
QT:{{”
Age-related macular degeneration results in blindness, and one major locus (HTRAX) accounts for approximately one-half of genetic cases. “}}
Should be HTRA1
http://ghr.nlm.nih.gov/condition/age-related-macular-degeneration
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