Posts Tagged ‘pgenes’

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases

June 14, 2026

Might be useful to interrelated with pgenes

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases https://www.nature.com/articles/d41586-025-00217-w

also:

https://www.nature.com/articles/d41586-026-01492-x
Callaway, E. (2026). Revealed: the mysterious ‘dark’ proteins that might play a big role in biology. Nature.
https://doi.org/10.1038/d41586-026-01492-x

Note EXCLUDED in the below
QT:{{”
However, some scientists say there might be thousands more ‘dark proteins’ with unknown but potentially important roles in cells. These proteins and the genes that encode them have been excluded from databases of known human genes and proteins.
An effort announced today in Nature1 gives thousands of these molecules encoded by the human genome an official, new name — peptideins — and marks their inclusion in major gene and protein databases used by the life-sciences community.
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One-and-Done Heart Disease Prevention? Scientists Show It May Be Possible.

June 7, 2026

uses PCSK9, a human KO – a pgene motivation
One-and-Done Heart Disease Prevention? Scientists Show It May Be Possible. – The New York Times
https://www.nytimes.com/2026/05/25/health/cholesterol-ldl-gene-therapy.html

Platypus genome

May 5, 2021

https://www.nytimes.com/2021/01/09/science/platypus-genome-echidna.amp.html

The Evolutionary Origin of Descending Testicles – The New York Times

August 17, 2018

https://www.nytimes.com/2018/06/29/science/descending-testicles-evolution.html

High-throughput discovery of novel developmental phenotypes : Nature : Nature Research

September 22, 2016

HTP discovery of novel developmental #phenotypes
http://www.nature.com/nature/journal/v537/n7621/full/nature19356.html New list of essential genes for the mouse, upping number to ~2900

Kruglyak paper on C. elegans

January 2, 2014

A paper on C. elegans that’s very informative:
http://www.nature.com/ng/journal/v44/n3/full/ng.1050.html
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

Most notable of their findings is evidence of recent selective sweeps on chromosomes I, IV, V and (sort of) X. These sweeps have the potential to fix pseudogenes that might have been present at the time.