Posts Tagged ‘network’

Addressing the minimum fleet problem in on-demand urban mobility | Nature

August 17, 2018

Addressing the minimum fleet problem in on-demand urban mobility by @mmvazifeh, @stevenstrogatz et al.
https://www.Nature.com/articles/s41586-018-0095-1 Solved by putting taxis & their riders into a large #network

Network propagation: a universal amplifier of genetic associations : Nature Reviews Genetics : Nature Research

September 11, 2017

#Network propagation [by Markov walks, heat flow, diffusion, &c]: a universal amplifier of genetic associations
http://www.Nature.com/nrg/journal/v18/n9/abs/nrg.2017.38.html

Lenore Cowen,
Trey Ideker,
Benjamin J. Raphael
& Roded Sharan

http://www.nature.com/nrg/journal/v18/n9/abs/nrg.2017.38.html?foxtrotcallback=true

Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells

August 14, 2017

Naldi, A. et al. Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells. PLOS Computational Biology 13, e1005432 (2017).

Reconstruction & signal propagation analysis of the Syk signaling #network http://journals.PLoS.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005432 Inferring potential targets of the kinase

Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak — NEJM

July 22, 2017

WGS & Social-#Network Analysis of a TB Outbreak http://www.NEJM.org/doi/full/10.1056/NEJMoa1003176 Nice tech combo but not sure transmission & phylogeny are consistent

Mind the gaps: The holes in your brain that make you smart

June 10, 2017

Mind the gaps: The holes in your brain…make you smart
https://www.NewScientist.com/article/mg23331180-300-mind-the-gaps-the-holes-in-your-brain-that-make-you-smart/ Contrasts connectivity from graphs vs large-scale topology

Network Analysis: 60-second animation shows how divided Congress has become over the last 60 years

June 9, 2017

#Network Analysis [highlighting #modularity change]: Animation shows how divided Congress has become over…60 yrs https://www.YouTube.com/watch?v=tEczkhfLwqM

Network analytics in the age of big data | Science

April 2, 2017

#Network analytics in the age of #BigData
http://science.ScienceMag.org/content/353/6295/123.full Emphasizes analyzing connectivity of graph structures (eg motifs) v nodes

QT:{{”
To mine the wiring patterns of networked data and uncover the functional organization, it is not enough to consider only simple descriptors, such as the number of interactions that each entity (node) has with other entities (called node degree), because two networks can be identical in such simple descriptors, but have a very different connectivity structure (see the figure). Instead, Benson et al. use higher-order descriptors called graphlets (e.g., a triangle) that are based on small subnetworks obtained on a subset of nodes in the data that contain all interactions that appear in the data (3). They identify network regions rich in instances of a particular graphlet type, with few of the instances of the particular graphlet crossing the boundaries of the regions. If the graphlet type is specified in advance, the method can uncover the nodes interconnected by it, which enabled Benson et al. to group together 20 neurons in the nematode worm neuronal network that are known to control a particular type of movement. In this way, the method unifies the local wiring patterning with higher-order structural modularity imposed by it, uncovering higher-order functional regions in networked data. “}}

uri alon’s coherent/incoherent ffls

March 9, 2017

Function of the FFL network motif
http://www.PNAS.org/content/100/21/11980.abstract Decade-old work defining coherent & incoherent ones based on activation/repression

http://sites.fas.harvard.edu/~mcb195/lectures/Networks-II/Literature/pnas_Mangan03.pdf

A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human: Cell

February 24, 2017

FissionNet: Proteome-wide [pombe] Interactome Reveals #Network Evolution Principles
http://www.Cell.com/cell/abstract/S0092-8674(15)01556-1 Involving ~1300 soluble proteins

A scored human protein-protein interaction network to catalyze genomic interpretation : Nature Methods : Nature Research

December 9, 2016

Scored…PPI #network to catalyze genomic interpretation http://www.Nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4083.html >500k links from lit. mining; up weights small-scale expt