The MRC-Wellcome Trust Human Developmental Biology Resource (HDBR) HDBR EXPRESSION – An online resource for studying prenatal human brain development
http://www.hdbr.org/expression/
Posts Tagged ‘psychencode’
Human Developmental Biology Resource (HDBR)
October 21, 2016Single Cell Analysis paper
October 8, 201616 Neuronal subtypes & [inter-regional] diversity revealed by [#singlecell]-nucleus RNAseq of…the brain
http://science.sciencemag.org/content/352/6293/1586.long
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease: Cell
October 1, 2016Zhang, Bin, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, Alexei A. Podtelezhnikov, Chunsheng Zhang et al. "Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease." Cell 153, no. 3 (2013): 707-720.
Integrated systems approach identifies genetic…#networks in…Alzheimer’s http://www.Cell.com/cell/abstract/S0092-8674(13)00387-5 Determining causality from co-expression
The Brain That Couldn’t Remember – The New York Times
August 13, 2016The #Brain That Couldn’t Remember
http://www.NYTimes.com/2016/08/07/magazine/the-brain-that-couldnt-remember.html Fight over the ownership of HM’s highlights issues in consent HT @FearLoathingBTX
What Dead Pigs Can’t Teach Us About ‘C.S.I.’
July 24, 2016What Dead Pigs Can’t Teach Us About @CSI_CBS
http://www.nytimes.com/2016/06/14/science/forensic-science-body-farm.html Wonder what this tells us about RIN? #RNAseq
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer | Genome Biology | Full Text
April 17, 2016two papers for journal club:
1. What are super-enhancers? Pott et al., Nature Genetics (2015) http://www.nature.com/ng/journal/v47/n1/full/ng.3167.html
2. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer, Heyn et al., Genome Biology (2016)
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0879-2
#Epigenomic analysis detects aberrant super-enhancer DNA methylation in human #cancer
https://GenomeBiology.biomedcentral.com/articles/10.1186/s13059-016-0879-2 hypo-Me of many large blocks
Runs in the Family – The New Yorker
April 11, 2016Runs in the Family
http://www.newyorker.com/magazine/2016/03/28/the-genetics-of-schizophrenia Overview of recent results that #SCZ is due to synaptic overpruning from excessive C4 activity
QT:{{”
A magnificently simple theory began to convulse out of the results. Perhaps C4A, like the other immunological factors that Stevens had identified in synapse pruning, marks neuronal synapses destined to be eliminated during normal brain development. During the maturation of the brain, microglia recognize these factors as tags and engulf the tagged synapses. Variations in the C4A gene cause different amounts of the C4A protein to be expressed in the human brain. The overabundance of C4A protein in some people contributes to an excessively exuberant pruning of synapses—thereby decreasing the number of synapses in the brain, which would explain the well-established fact that
schizophrenic patients tended to have fewer neuronal connections. That the symptoms of schizophrenia break loose during the second and third decades of life makes sense, in retrospect: adolescence and early adulthood are periods when synaptic pruning reaches a climax in the regions of the brain that govern planning and thinking.
“}}
Seeking the Gears of Our Inner Clock – The New York Times
February 29, 2016gene expression rhythms in brain & relation to time of death
http://www.nytimes.com/2015/12/29/science/seeking-the-gears-of-our-inner-clock.html
Seeking the Gears of Our Inner Clock – The New York Times
February 29, 2016gene expression rhythms in brain & relation to time of death
http://www.nytimes.com/2015/12/29/science/seeking-the-gears-of-our-inner-clock.html
Cell type- and brain region-resolved mouse brain proteome : Nature Neuroscience : Nature Publishing Group
December 13, 2015Celltype & region–resolved mouse brain proteome
http://www.nature.com/neuro/journal/v18/n12/full/nn.4160.html proteins enriched there v liver & in specific regions (eg NCX v STR)
http://www.nature.com/neuro/journal/v18/n12/full/nn.4160.html
linkstream2 microblog 