Posts Tagged ‘quote’

The Creative Apocalypse That Wasn’t

September 4, 2015

The Creative Apocalypse That Wasn’t http://www.nytimes.com/2015/08/23/magazine/the-creative-apocalypse-that-wasnt.html "The Napsterization of culture…less of a threat…than it initially appeared."

QT:{{"

“This would be even more troubling if independent bookstores — traditional champions of the literary novel and thoughtful nonfiction — were on life support. But contrary to all expectations, these stores have been thriving. After hitting a low in 2007, decimated not only by the Internet but also by the rise of big-box chains like Borders and Barnes & Noble, indie bookstores have been growing at a steady clip, with their number up 35 percent (from 1,651 in 2009 to 2,227 in 2015); by many reports, 2014 was their most financially successful year in recent memory.

How do we explain the evolutionary niche that indie bookstores seem to have found in recent years? It may be as simple as the tactile appeal of books and bookstores themselves. After several years of huge growth, e-book sales have plateaued over the past two years at 25 to 30 percent of the market, telegraphing that a healthy consumer appetite for print remains. To many of us, buying music in physical form is now simply an inconvenience: schlepping those CDs home and burning them and downloading the tracks to our mobile devices. But many of the most ardent Kindle converts — and I count myself among them — still enjoy browsing shelves of physical books, picking them up and sitting back on the couch with them.

….
If you believe the data, then one question remains. Why have the more pessimistic predictions not come to pass? One incontrovertible reason is that — contrary to the justifiable fears of a decade ago — people will still pay for creative works. The Napsterization of culture turned out to be less of a threat to prices than it initially appeared. Consumers spend less for recorded music, but more for live. Most American households pay for television content, a revenue stream that for all practical purposes didn’t exist 40 years ago. Average movie-­ticket prices continue to rise. For interesting reasons, book piracy hasn’t taken off the way it did with music.
….

The biggest change of all, perhaps, is the ease with which art can be made and distributed. The cost of consuming culture may have declined, though not as much as we feared. But the cost of producing it has dropped far more drastically. Authors are writing and publishing novels to a global audience without ever requiring the service of a printing press or an international distributor. For indie filmmakers, a helicopter aerial shot that could cost tens of thousands of dollars a few years ago can now be filmed with a GoPro and a drone for under $1,000; some directors are shooting entire HD-­quality films on their iPhones. Apple’s editing software, Final Cut Pro X, costs $299 and has been used to edit Oscar-­winning films. A musician running software from Native Instruments can recreate, with astonishing fidelity, the sound of a Steinway grand piano played in a Vienna concert hall, or hundreds of different guitar-­amplifier sounds, or the Mellotron proto-­synthesizer that the Beatles used on ‘‘Strawberry Fields Forever.’’ These sounds could have cost millions to assemble 15 years ago; today, you can have all of them for a few thousand dollars.”
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The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

August 28, 2015

[Population] genetics of Mexico by @cdbustamante lab
http://www.sciencemag.org/content/344/6189/1280.abstract Has groups as divergent from each other as Europeans v Asians

QT:{{”
We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians.
Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country.

The genetics of indigenous Mexicans exhibit substantial geographical structure, some as divergent from each other as are existing populations of Europeans and Asians.
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Eye Shape May Help Distinguish Predator From Prey

August 28, 2015

#Eye Shape May Help Distinguish Predator From Prey
http://www.nytimes.com/2015/08/08/science/eye-shape-may-help-distinguish-predator-from-prey.html Vertical v horzonital slits, resp., for depth v field-of-view

QT:{{”
“Why do the eyes of some animals, including goats, have
horizontal-shaped pupils, while others, such as rattlesnakes and domestic cats, have vertical slits?

It is a question that has longed intrigued researchers, and a study of 214 species published Friday suggests the answer may be strongly linked to giving animals a survival edge: vertical pupils and circular pupils help certain predators hunt, while horizontal pupils help other species spot predators from afar.”
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We’ll see you, anon

August 28, 2015

We’ll see you, anon
http://www.economist.com/news/science-and-technology/21660966-can-big-databases-be-kept-both-anonymous-and-useful-well-see-you-anon “A dilemma. People want perfect #privacy & all the benefits of openness.” Math to the rescue?

Good for an intro. on privacy & attacks

QT:{{”

This is a true dilemma. People want both perfect privacy and all the benefits of openness. But they cannot have both.

“While some level of anonymisation will remain part of any resolution of the dilemma, mathematics may change the overall equation. One approach that would shift the balance to the good is homomorphic encryption, whereby queries on an encrypted data set are themselves encrypted. The result of any inquiry is the same as the one that would have been obtained using a standard query on the unencrypted database, but the questioner never sets eyes on the data. Or there is secure multiparty computation, in which a database is divided among several repositories. Queries are thus divvied up so that no one need have access to the whole database.

These approaches are, on paper, absolute in their protections. But putting them to work on messy, real-world data is proving tricky. Another set of techniques called differential privacy seems further ahead. The idea behind it is to ensure results derived from a database would look the same whether a given individual’s data were in it or not. It works by adding a bit of noise to the data in a way that does not similarly fuzz out the statistical results.


America’s Census Bureau has used differential privacy in the past for gathering commuters’ data. Google is employing it at the moment as part of a project in which a browser plug-in gathers lots of data about a user’s software, all the while guaranteeing anonymity. Cynthia Dwork, a differential-privacy pioneer at Microsoft Research, suggests a more high-profile proving ground would be data sets—such as some of those involving automobile data or genomes—that have remained locked up because of privacy concerns.”
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Lanosterol reverses protein aggregation in cataracts : Nature : Nature Publishing Group

August 17, 2015

Lanosterol reverses protein aggregation in cataracts
http://www.nature.com/nature/journal/v523/n7562/full/nature14650.html A finding from rare-disease #exome sequencing cc @solvemendelian

QT:{{”
…Lanosterol is an
amphipathic molecule enriched in the lens. It is synthesized by lanosterol synthase (LSS) in a key cyclization reaction of a cholesterol synthesis pathway. Here we identify two distinct homozygousLSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts. Both of these mutations affect highly conserved amino acid residues and impair key catalytic functions of LSS. Engineered expression of wild-type, but not mutant, LSSprevents intracellular protein aggregation of various
cataract-causing mutant crystallins.
“}}

The Fatigue Conundrum » American Scientist

August 17, 2015

The #Fatigue Conundrum
http://www.americanscientist.org/issues/feature/2015/3/the-fatigue-conundrum/99999 Safety v cost cutting: ~”Delta saved $250k/yr by
shaving an oz from each steak it served”

QT:{{”
Such narrow profit margins, coupled with volatile fuel prices (which today account for up to 40 percent of operating expenses as compared with only 15 percent a few decades ago), mean that airlines are continuously looking for ways to cut costs. According to a report in the New York Times, Delta Airlines saved $250,000 in one year by shaving an ounce from each of the steaks it served on board, whereas American Airlines is said to have saved $40,000 a year by removing a single olive from every salad it served to passengers.
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Glypican-1 identifies cancer exosomes and detects early pancreatic cancer : Nature : Nature Publishing Group

August 16, 2015

[Protein] Glypican-1 [uniquely] identifies [circulating] cancer #exosomes & detects…cancer
http://www.nature.com/nature/journal/v523/n7559/full/nature14581.html Maybe also for @exRNA

QT:{{”
Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic acids. They are secreted by all cells and circulate in the blood. Specific detection and isolation of
…we identify a cell surface
proteoglycan, glypican-1 (GPC1), specifically enriched on
cancer-cell-derived exosomes. GPC1+ circulating exosomes (crExos) were monitored …”}}

http://www.nature.com/nature/journal/v523/n7559/full/nature14581.html

No assembler required | The Economist

August 16, 2015

No assembler required
http://www.economist.com/news/science-and-technology/21660077-how-teach-computer-science-nursery-school-no-assembler-required KIBO, Dash, Vortex & Hackaball provide a playful way to learn #programming

QT:{{”
Dr Umaschi Bers is not alone in that quest. KIBO, made by KinderLab Robotics (of which she is chief science officer when she is not doing her day job), is unusual only in that its instruction set is so tied to physical objects. Other toys being developed to teach young children the rudiments of programming use not wooden blocks but blocks of code, presented as icons of various sorts on the screens of tablets, smartphones and even old-fashioned PCs. Instead of being scanned, these instructions are uploaded wirelessly to the robots they are intended to control—robots that come in all sorts of shapes and sizes.

Some, like Vortex (a wheeled device that resembles a flattened motorcycle helmet) and Dash (a tetrahedron of spheres which, besides moving around at its programmer’s command, can also play tunes on a glockenspiel), are, like KIBO, designed mainly to scuttle across the living-room floor. Others, though, are heading in a different direction.
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When Fantasy Sports Beat Real Ones

August 9, 2015

Dream teams http://www.newyorker.com/magazine/2015/04/13/dream-teams The “Gamification of Fandom,” making the fans into the players & the players into statistical pawns

QT:{{”

The fan of the not too distant future, Goldstein said, will want better telecom service within the stadiums so that he can follow his fantasy teams at the same time as he is watching the game. “You’ll have an iPad mounted into the seat, and on that iPad you’ll have the RedZone channel,” he said. “Can you imagine? I pay, I can lean back, I can sit, and I can be in my living room—but in the stadium. That’s what we’re doing in the theatres.”

What explains the temptation to make games of the watching of games? Last month, I joined Fantasy Iditarod, and the two or three hours that I spent compiling my team of Alaskan dog mushers were a nirvana of pure concentration. I had twenty-seven thousand “dollars” to spend on seven sled drivers, whose “salaries” were calibrated such that you couldn’t just stock up on favorites and former champions. The process reminded me of something Dan Okrent said, when describing what he called the “one, overriding positive contribution” that Rotisserie baseball had made to the actual sport, which was that, after you started playing,

The gamification of fandom is alluring because it provides an application for the things you’ve learned—or think you’ve learned—in the course of wasting so much time that could have been spent reading Proust, or playing with your kids, or donating blood. It’s a hedge against existential despair, a measurable opportunity to “succeed” at what might otherwise be called futility. I went to Alaska on assignment a couple of years ago, to see the Iditarod in person, and was sufficiently transfixed by the new sporting subculture that I’ve continued to follow its developments from afar.

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One big myth about medicine: We know how drugs work

August 8, 2015

Big myth about medicine: We know how #drugs work
http://www.washingtonpost.com/blogs/wonkblog/wp/2015/07/23/one-big-myth-about-medicine-we-know-how-drugs-work “If you only half-know something, you can appreciate serendipity”
QT:{{“

If you think you’re too smart and you only do what is scientifically indicated, there’s always going to be something, ‘Oh my God, we never thought of that!’” Haber said. “If you half-know what you’re doing, then you’re better prepared to understand or appreciate discoveries that are serendipitous in some way.”

A 2011 study reviewed a decade worth of drug approvals found that of 75 drugs that worked in a completely new way, 28 came from the more old-fashioned method of screening drugs against cells or animals, and 17 were built from detailed understanding of how the disease worked. David Swinney of the Institute for Rare and Neglected Diseases Drug Discovery said that despite the fact that far more resources are devoted to developing drugs by focusing on targets, the older method of screening has been more productive by his analysis.”
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