Structural networks of signaling pathways
http://www.sciencedirect.com/science/article/pii/S0959440X1200070X Prism on IL10 #networks, mapping on Cosmic, disrupting mutations as drivers
Posts Tagged ‘structint’
Constructing structural networks of signaling pathways on the proteome scale
September 6, 2014Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Asso ciation” Principle
August 7, 2014Inheritance Modes in… #Network Challenges… Guilt-by-Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751 #Diseases of recessive interface SNVs predictable
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751/
surprisingly, no positional effects on LOF mutations … significant proportion of truncation alleles give rise to functional products
“guilt by assoc works”
signif. number dom mut give rise to func products
Exploring mechanisms of human disease through structurally resolved protein interactome networks
July 19, 2014Mol Biosyst. Author manuscript; available in PMC Jul 1, 2014. Published in final edited form as:
Mol Biosyst. Jan 2014; 10(1): 9–17.
doi: 10.1039/c3mb70225a
Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Asso ciation” Principle
July 19, 2014http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751/
surprisingly, no positional effects on LOF mutations … significant proportion of truncation alleles give rise to functional products
“guilt by assoc works”
signif. number dom mut give rise to func products
