miRNA silencing for…therapy targeted to the [acidic] tumor microenviron., w/ #pHLIP
http://www.nature.com/nature/journal/v518/n7537/abs/nature13905.html miR-155 moves beyond biomarker
Posts Tagged ‘talk’
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment : Nature : Nature Publishing Group
April 8, 2016DREM 2.0: Improved reconstruction of dynamic regulatory networks from time-series expression data | BMC Systems Biology | Full Text
April 8, 2016DREM…reconstruction of…regulatory #networks from time-series expression http://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-6-104 Classic approach using 3-level IO #HMMs
Visualizing virus assembly intermediates inside marine cyanobacteria : Nature : Nature Publishing Group
June 16, 2015Visualizing virus assembly…inside…bacteria
http://www.nature.com/nature/journal/v502/n7473/full/nature12604.html Phase-contrast #cryoET resolves subcellular structures (eg ribosomes)
Cryo-ET determines diff structural snapshots virus during assembly. One tomogram to work out whole pathway.
Wei Dai,
Caroline Fu,
Desislava Raytcheva,
John Flanagan,
Htet A. Khant,
Xiangan Liu,
Ryan H. Rochat,
Cameron Haase-Pettingell,
Jacqueline Piret,
Steve J. Ludtke,
Kuniaki Nagayama,
Michael F. Schmid,
Jonathan A. King
& Wah Chiu
Nature 502, 707–710 (31 October 2013) doi:10.1038/nature12604
ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma: Cancer Cell
May 22, 2015ALK Mutations Confer Differential Oncogenic Activation
http://www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900393-6 MD modeling better assessing #SNV impact than stats, ie sift
ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma
Scott C. Bresler
Daniel A. Weiser
Peter J. Huwe
…
Ravi Radhakrishnan
Mark A. Lemmon
Yaël P. Mossé
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
March 27, 2015RUNX1 is most connected in TLX1 & 3 expr. net. It’s a tumor suppressor disabled by LOF mutations.
Rev. engineering…identifies RUNX1 as tumor suppressor in T-ALL http://www.nature.com/nm/journal/v18/n3/full/nm.2610.html It’s the most connected TF in the expression network
Nat Med. Author manuscript; available in PMC 2012 Sep 1.
Nat Med. 2012 Feb 26; 18(3): 436–440.
Published online 2012 Feb 26. doi: 10.1038/nm.2610
Giusy Della Gatta,1 Teresa Palomero,1,2 Arianne Perez-Garcia,1 Alberto Ambesi-Impiombato,1 Mukesh Bansal,3Zachary W. Carpenter,1 Kim De Keersmaecker,4,5 Xavier Sole,6,7 Luyao Xu,1 Elisabeth Paietta,8,9 Janis Racevskis,8,9Peter H Wiernik,8,9 Jacob M Rowe,10 Jules P Meijerink,11 Andrea Califano,1,3 and Adolfo A. Ferrando1,2,12
Convergent transcriptional specializations in the brains of humans and song-learning birds
March 15, 2015Convergent…specializations in brains of humans & songbirds http://www.sciencemag.org/content/346/6215/1256846.long Both have matching expression patterns across regions
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
February 21, 2015Human & mouse [mRNA] #methylomes revealed by m6A-seq http://www.nature.com/nature/journal/v485/n7397/full/nature11112.html Conservation across species & conditions (for most sites)
Dan Dominissini,
Sharon Moshitch-Moshkovitz,
Schraga Schwartz,
…
Rotem Sorek
& Gideon Rechavi
Nature 485, 201–206 (10 May 2012) doi:10.1038/nature11112
High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
February 21, 2015High-res mapping reveals a conserved…mRNA methylation program http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956118/ Predicting methyl sites w/ seq., structure & position
Cell. 2013 Dec 5; 155(6): 1409–1421.
Published online 2013 Nov 21. doi: 10.1016/j.cell.2013.10.047 PMCID: PMC3956118
NIHMSID: NIHMS550466
High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
Schraga Schwartz,1,* Sudeep D. Agarwala,2,* Maxwell R. Mumbach,1 Marko Jovanovic,1 Philipp Mertins,1 Alexander Shishkin,1 Yuval Tabach,3,4 Tarjei S Mikkelsen,1 Rahul Satija,1 Gary Ruvkun,3,4 Steven A. Carr,1 Eric S. Lander,1,5,6 Gerald R. Fink,1,2,8 and Aviv Regev 1,7,8
Privacy in Pharmacogenetics: An End-to-End Case Study of Personalized Warfarin Dosing | USENIX
February 20, 2015Privacy in Pharmacogenetics…Personalized Warfarin Dosing
https://www.usenix.org/conference/usenixsecurity14/technical-sessions/presentation/fredrikson_matthew Model-inversion attack; differential privacy doesn’t help
Authors:
Matthew Fredrikson, Eric Lantz, and Somesh Jha, University of Wisconsin—Madison; Simon Lin, Marshfield Clinic Research Foundation; David Page and Thomas Ristenpart, University of Wisconsin—Madison
Awarded Best Paper!
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